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Related Concept Videos

Heart Valves01:16

Heart Valves

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The human heart is a complex organ with an intricate system of valves that regulate blood flow. There are two main types of valves: atrioventricular (AV) valves and semilunar valves.
The AV valves prevent the backflow of blood from the ventricles to the atria during ventricular contraction. These valves function with the assistance of the chordae tendineae and papillary muscles. When the ventricles are relaxed, the chordae tendineae are slack, allowing blood to flow from the atria into the...
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Mitochondria01:37

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Mitochondria are eukaryotic cellular organelles that are known to produce energy through a process called oxidative phosphorylation. Besides their primary function, mitochondria are involved in various cellular processes, including cell growth, differentiation, signaling, metabolism, and senescence. Age-related changes cause a decline in mitochondrial quality and integrity due to increased mitochondrial mutations and oxidative damage. Thus, aging can severely impact mitochondrial functions,...
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Cardiovascular System Abnormal Findings II: Auscultation01:25

Cardiovascular System Abnormal Findings II: Auscultation

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Auscultation, an essential part of a heart examination, is done using a stethoscope. It provides crucial information about heart function and possible heart problems. Due to heart problems, abnormal sounds can be heard during systole or diastole. These sounds include S3 and S4 gallops, opening snaps, systolic clicks, and murmurs.
Abnormal Heart Sounds
Gallops:
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Related Experiment Video

Updated: Jun 14, 2025

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An Update on Mitral Valve Aging.

Carmen Elena Opris1,2, Horatiu Suciu3,4,5, Cosmin Ioan Opris3

  • 1Department of Adult and Children Cardiovascular Recovery, Emergency Institute for Cardio-Vascular Diseases and Transplantation, 540139 Targu Mures, Romania.

Life (Basel, Switzerland)
|August 29, 2024
PubMed
Summary

Aging significantly impacts the mitral valve, altering its structure and function. Understanding these age-related changes is key to improving diagnosis and treatment for cardiovascular complications in older adults.

Keywords:
agingheartmitral valve

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Area of Science:

  • Cardiovascular Science
  • Gerontology
  • Biomedical Engineering

Background:

  • The aging process induces progressive structural and functional changes in the mitral valve.
  • Mitral valve aging is a significant factor in age-related cardiovascular disease.

Purpose of the Study:

  • To provide a comprehensive review of literature on mitral valve aging up to February 2024.
  • To synthesize current knowledge on age-related mitral valve transformations.

Main Methods:

  • Systematic literature search of the Medline database up to February 2024.
  • Selection and analysis of 73 highly informative publications on mitral valve aging.
  • Integration of authors' clinical experience with published data.

Main Results:

  • Identified 308 publications related to mitral valve aging in the elderly from a total of 12,189 relevant studies.
  • Analysis focused on 73 key works detailing age-related mitral valve changes.
  • Synthesized findings on the mechanisms of mitral valve aging.

Conclusions:

  • Understanding mitral valve aging mechanisms is critical for clinical practice.
  • Enhanced knowledge can improve diagnostic and therapeutic strategies for age-related valve dysfunction.
  • This review highlights the importance of addressing mitral valve aging to prevent cardiovascular complications.