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Related Concept Videos

Lytic Cycle of Bacteriophages01:30

Lytic Cycle of Bacteriophages

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Bacteriophages, also known as phages, are specialized viruses that infect bacteria. A key characteristic of phages is their distinctive “head-tail” morphology. A phage begins the infection process (i.e., lytic cycle) by attaching to the outside of a bacterial cell. Attachment is accomplished via proteins in the phage tail that bind to specific receptor proteins on the outer surface of the bacterium. The tail injects the phage’s DNA genome into the bacterial cytoplasm. In the...
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Lysogenic Cycle of Bacteriophages00:43

Lysogenic Cycle of Bacteriophages

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In contrast to the lytic cycle, phages infecting bacteria via the lysogenic cycle do not immediately kill their host cell. Instead, they combine their genome with the host genome, allowing the bacteria to replicate the phage DNA along with the bacterial genome. The incorporated copy of the phage genome is called the prophage. Some prophages can re-activate and enter the lytic cycle. This often occurs in response to a perturbation, such as DNA damage, but can also transpire in the absence of...
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Related Experiment Video

Updated: Jun 14, 2025

Genetic Modification of Cyanobacteria by Conjugation Using the CyanoGate Modular Cloning Toolkit
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Genetic Modification of Cyanobacteria by Conjugation Using the CyanoGate Modular Cloning Toolkit

Published on: October 31, 2019

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Efficient Broad-Spectrum Cyanophage Function Module Mining.

Yujing Guo1, Xiaoxiao Dong2, Huiying Li1

  • 1Beijing Advanced Innovation Center for Soft Matter Science and Engineering, Beijing University of Chemical Technology, Beijing 100029, China.

Microorganisms
|August 29, 2024
PubMed
Summary
This summary is machine-generated.

Researchers explored cyanophage genomes to enhance biological bloom control. They identified essential gene modules and used mutagenesis to create more effective cyanophages, improving bloom management strategies.

Keywords:
cyanobacteria bloomscyanophagefunction modulegene function

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Phage Phenomics: Physiological Approaches to Characterize Novel Viral Proteins
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Phage Phenomics: Physiological Approaches to Characterize Novel Viral Proteins

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Area of Science:

  • Environmental microbiology
  • Virology
  • Biotechnology

Background:

  • Cyanobacterial harmful algal blooms (CyanoHABs) pose global health and environmental risks.
  • Cyanophages, viruses infecting cyanobacteria, offer a promising biological control method for CyanoHABs.
  • Limited genomic data and uncharacterized proteins in cyanophages hinder their application.

Purpose of the Study:

  • To investigate the essential genes and functional modules of the cyanophage YongM.
  • To generate and analyze enhanced cyanophage modules through mutagenesis for improved bloom control efficacy.

Main Methods:

  • Rational analysis of essential genes to define a minimal cyanophage genome.
  • Construction and assessment of single essential gene modules.
  • Ultraviolet mutagenesis of cyanophage YongM to create novel gene modules.
  • Sequencing and functional analysis of mutated gene modules.

Main Results:

  • Identification of essential gene modules critical for cyanophage function.
  • Generation of mutant cyanophage modules with potentially enhanced efficiency.
  • Characterization of novel protein functions within cyanophage genomes.

Conclusions:

  • The study provides insights into the functional components of cyanophage genomes.
  • Identified gene modules can advance the development of effective biological agents for CyanoHAB mitigation.
  • Further research on cyanophage genomics is crucial for optimizing bloom control strategies.