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Association between Accelerated Biological Aging, Diet, and Gut Microbiome
Shweta Sharma1,2, Anna Prizment1, Heather Nelson2
1Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN 55455, USA.
Microorganisms
|August 29, 2024
Summary
Dietary fiber intake and processed meat consumption impact biological age. Higher fiber intake is linked to a younger biological age, while processed meat is associated with accelerated aging, particularly when gut microbiome is considered.
Area of Science:
- Nutritional Science
- Microbiome Research
- Aging Biology
Background:
- Accelerated biological age (BA) is a predictor of chronic diseases, but its drivers are not fully understood.
- Diet and gut microbiome are hypothesized to influence BA, necessitating further investigation.
Purpose of the Study:
- To investigate the cross-sectional associations between diet, gut microbiome, and accelerated Klemera-Doubal biological age (KDM-BA).
Main Methods:
- 117 adult participants from the 10,000 Families Study were analyzed.
- 16S rRNA sequencing identified gut bacterial genera.
- Multivariable linear mixed models assessed associations, adjusting for confounders.
Main Results:
- Increased processed meat intake correlated with higher accelerated KDM-BA (1.91 years/SD increase).
- Increased fiber intake correlated with lower accelerated KDM-BA (0.70 years/SD decrease).
- Accelerated KDM-BA showed positive associations with *Streptococcus* and negative associations with *Subdoligranulum*, unclassified *Bacteroidetes*, and *Burkholderiales*.
Conclusions:
- Dietary fiber and processed meat intake are associated with accelerated biological age.
- The association between processed meat and accelerated BA was attenuated after adjusting for gut microbiome composition.
- Further longitudinal studies are needed to validate these findings.
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