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Leukocyte migration inhibition in recurrent aphthous ulceration
Journal of Oral Pathology
|February 1, 1985
Summary
Leukocyte inhibitory factor (LIF) production does not appear to cause recurrent aphthous ulceration (RAU). This study found no significant link between LIF responses to streptococcal antigens or oral mucosa and RAU development.
Area of Science:
- Immunology
- Oral Medicine
- Microbiology
Background:
- Recurrent aphthous ulceration (RAU) is a common oral condition.
- The pathogenic mechanisms of RAU are not fully understood.
- Leukocyte inhibitory factor (LIF) has been investigated as a potential factor.
Purpose of the Study:
- To investigate the role of Leukocyte Inhibitory Factor (LIF) production in the pathogenesis of recurrent aphthous ulceration (RAU).
- To determine if specific immune responses to streptococcal antigens or oral mucosa are involved in RAU.
Main Methods:
- Mononuclear cells from RAU patients and healthy controls were stimulated with streptococcal antigens and oral mucosa.
- Leukocyte migration inhibition assays were performed.
- LIF production was monitored in relation to ulcer development in a sequential study.
Main Results:
- Some statistically significant differences in leukocyte migration inhibition were observed between RAU patients and controls for certain streptococcal species and Candida albicans.
- A trend towards lower migration indices was noted with oral mucosa.
- However, the responses were not consistently significant or biologically relevant, and LIF production did not correlate with ulcer development.
Conclusions:
- Leukocyte inhibitory factor (LIF) production, in response to the tested antigens, does not play a pathogenic role in recurrent aphthous ulceration (RAU).
- The data do not support a hypothesis of cell-mediated sensitivity to streptococcal antigens in RAU.