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Targeted Cancer Therapies

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...

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Related Experiment Video

Updated: Jun 14, 2025

Preparation and Characterization of Individual and Multi-drug Loaded Physically Entrapped Polymeric Micelles

Preparation and Characterization of Individual and Multi-drug Loaded Physically Entrapped Polymeric Micelles

Published on: August 28, 2015

Functionalized Polymeric Micelles for Targeted Cancer Therapy: Steps from Conceptualization to Clinical Trials.

Ana Serras¹, Célia Faustino¹, Lídia Pinheiro¹

¹Research Institute for Medicines (iMed.ULisboa), Faculdade de Farmácia, Universidade de Lisboa (ULisboa), Avenida Professor Gama PintoGama Pinto, 1649-003 Lisboa, Portugal.

|August 29, 2024

Summary

Polymeric micelles (PMs) offer a promising nanomedicine approach to overcome chemotherapy limitations. These smart drug delivery systems (SDDSs) enhance drug efficacy and safety, advancing cancer treatment from preclinical to clinical stages.

Keywords:

amphiphilic polymers cancer clinical trials nanomedicine polymeric micelles stimuli-responsive micelles targeted drug delivery

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Area of Science:

Nanomedicine and Drug Delivery Systems
Oncology Therapeutics

Background:

Cancer remains a leading cause of death, with chemotherapy facing challenges like toxicity, poor bioavailability, and multidrug resistance.
Nanomedicine has emerged as a field to develop advanced therapeutics with improved properties.
Smart drug delivery systems (SDDSs) are crucial for enhancing drug delivery and therapeutic outcomes.

Purpose of the Study:

To review polymeric micelles (PMs) as a specific type of SDDS for cancer therapy.
To focus on PMs that have progressed from preclinical studies to clinical trials.
To examine the journey of PM-based nanotherapeutics towards market introduction.

Main Methods:

Review of scientific literature focusing on nanomedicine and polymeric micelles in cancer treatment.
Analysis of preclinical data and clinical trial progress for PM-based nanotherapeutics.
Evaluation of the development pathway from laboratory research to clinical application.

Main Results:

Polymeric micelles effectively encapsulate hydrophobic and toxic drugs, improving stability and bioavailability.
Preclinical studies demonstrate enhanced pharmacokinetic profiles, increased therapeutic efficacy, and improved safety of PMs.
Several PM formulations are advancing through clinical trials, indicating their therapeutic potential.

Conclusions:

Polymeric micelles represent a significant advancement in nanomedicine for cancer treatment.
PMs demonstrate potential to overcome major limitations of conventional chemotherapy.
The progression of PMs into clinical trials highlights their promise for future cancer therapies.