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A TIRF Microscopy Technique for Real-time, Simultaneous Imaging of the TCR and its Associated Signaling Proteins

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High Spatial Resolution Detector System Based on Reconfigurable Dual-FPGA Approach for Coincidence Measurements.

Marco Cautero^1,2, Fabio Garzetti³, Nicola Lusardi³

¹Dipartimento di Fisica, Università degli Studi di Trieste, 34127 Trieste, Italy.

Sensors (Basel, Switzerland)

|August 29, 2024

Summary

This summary is machine-generated.

This study presents a novel time-to-digital converter (TDC) using two field-programmable gate arrays (FPGAs) for high-precision particle detection. This advanced system achieves 12 picosecond temporal resolution, crucial for time-resolved spectroscopy and coincidence measurements.

Keywords:

cross delay-line (CDL)digitization of sensor data field-programmable gate array (FPGA)time-mode time-resolved experiments time-to-digital converter (TDC)

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Area of Science:

Physics
Chemistry
Materials Science

Background:

Time-resolved spectroscopic and electron-ion coincidence techniques require precise timing information.
Detectors need to provide spatial and temporal data (x, y, time) for detected particles.
Existing electronics often rely on time-to-digital converters (TDCs) and field-programmable gate arrays (FPGAs) for data acquisition.

Purpose of the Study:

To design and implement an innovative TDC system with high temporal resolution.
To enable advanced time-resolved measurements in materials and chemical analysis.
To develop a flexible data acquisition system for coincidence measurements.

Main Methods:

Implementation of a TDC using an AMD/Xilinx Artix® 7 FPGA for high-precision timing.
Utilizing an Intel Cyclone® 10 FPGA for data acquisition and external connectivity.
Optimizing the system for simultaneous eight-channel operation with potential for expansion.

Main Results:

Achieved a temporal precision of 12 picoseconds for the TDC.
Developed a symbiotic FPGA architecture for efficient data management.
Demonstrated suitability for multi-channel coincidence measurements.

Conclusions:

The designed TDC system meets the stringent requirements for advanced time-resolved studies.
The dual-FPGA approach offers a robust and scalable solution for particle detection.
This innovation facilitates precise temporal correlation in complex experimental setups.