Risk Factors Associated With Drug-Related Side Effects in Children: A Scoping Review.
Esmaeel Toni1, Haleh Ayatollahi1, Reza Abbaszadeh1
1Iran University of Medical Sciences, Tehran, Iran.
Global Pediatric Health
|August 29, 2024
Summary
Children are vulnerable to drug side effects. Key risk factors include young age, polypharmacy, and longer hospital stays, necessitating further research into pediatric drug safety.
Area of Science:
- Pediatric Pharmacology
- Drug Safety Research
- Adverse Drug Event Analysis
Background:
- Children exhibit heightened vulnerability to adverse drug reactions (ADRs).
- Existing research lacks consensus on specific risk factors for pediatric ADRs.
- Understanding these factors is crucial for improving child patient safety.
Purpose of the Study:
- To conduct a comprehensive scoping review of risk factors for drug-related side effects in children.
- To identify and categorize potential demographic, health, hospital, and drug-specific risk factors.
- To synthesize current knowledge on pediatric adverse drug events (ADEs).
Main Methods:
- A systematic scoping review methodology was employed.
- Searches were conducted across multiple scientific databases.
- Data extraction focused on pre-determined risk factors for predictable drug side effects.
Main Results:
- Identified risk factors encompass demographic, health, hospital, and drug-related categories.
- Factors significantly increasing risk include younger age, sex, polypharmacy, prolonged hospitalization, and use of medications for comorbidities.
- These findings highlight specific vulnerabilities in pediatric populations.
Conclusions:
- While some risk factors for ADEs overlap between children and adults, their impact may differ significantly in pediatric patients.
- Further research is essential to elucidate the precise impact and mechanisms of these risk factors in children.
- This study underscores the need for tailored approaches to pediatric drug safety.
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