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Radioiodine internal dose coefficients specific for Koreans.

Tae-Eun Kwon1, Yoonsun Chung2, Choonsik Lee1

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This study created Korean-specific internal dose coefficients for radioiodine, finding lower thyroid doses for longer-lived isotopes compared to international standards. Korean dose coefficients offer more accurate assessments for this population.

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Area of Science:

  • Nuclear Medicine
  • Radiological Protection
  • Biokinetics

Background:

  • International Commission on Radiological Protection (ICRP) provides reference dose coefficients.
  • Existing models may not accurately reflect Korean physiological and anatomical characteristics.
  • Radioiodine isotopes are used in diagnostics and therapeutics, necessitating accurate dosimetry.

Purpose of the Study:

  • To develop internal dose coefficients for radioiodine specific to the Korean population.
  • To compare these Korean-specific coefficients with ICRP reference values.
  • To investigate the impact of population-specific biokinetics and phantom design on dose assessment.

Main Methods:

  • Incorporation of a Korean biokinetic model.
  • Utilization of Korean S values (absorbed fraction per unit cumulated activity).
  • Development of Korean reference phantoms for dose calculation.

Main Results:

  • Significant differences in thyroid dose coefficients for longer-lived iodine isotopes (I-125, I-129) between Korean and ICRP values (ratios 0.30-0.55).
  • Comparable thyroid dose coefficients for short-lived I-131 (ratios 0.95-0.98) due to offsetting factors.
  • Substantial variations in non-thyroidal and effective dose coefficients due to anatomical and technical differences.

Conclusions:

  • Korean-specific internal dose coefficients for radioiodine provide more precise dose assessments.
  • The use of these tailored coefficients is particularly recommended for scenarios involving potentially high radiation doses.
  • This study highlights the importance of population-specific dosimetry in radiological protection.