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Factors Influencing Liver Abnormalities in Psoriatic Arthritis Patients: A Comprehensive Study
Ping Seung Ong1, Lay Kim Tan2, Hasnah Mat2
1Rheumatology Unit, Department of Medicine, Hospital Raja Permaisuri Bainun, Jalan Raja Ashman Shah, Ipoh, Perak, Malaysia.
Psoriatic arthritis patients with longer disease duration, diabetes, or non-alcoholic fatty liver disease (NAFLD) face higher risks of liver abnormalities. Regular liver function monitoring is crucial for early detection and management in these individuals.
Area of Science:
- Rheumatology
- Hepatology
- Clinical Research
Background:
- Psoriatic arthritis (PsA) is a chronic inflammatory condition.
- Liver abnormalities can be a comorbidity in PsA patients.
- Identifying risk factors for liver issues in PsA is essential for patient care.
Purpose of the Study:
- To determine the incidence of liver enzyme abnormalities in psoriatic arthritis patients.
- To identify factors associated with the development of liver abnormalities in this cohort.
Main Methods:
- A longitudinal cohort study design was employed.
- Psoriatic arthritis patients with and without liver enzyme abnormalities were analyzed.
- Univariate and multivariate logistic regression analyses were used to identify associated factors.
Main Results:
- Out of 247 PsA patients, 99 showed liver enzyme abnormalities.
- Increased disease duration, diabetes mellitus, and non-alcoholic fatty liver disease (NAFLD) were significantly associated with liver abnormalities.
- No association was found with conventional synthetic disease-modifying antirheumatic drugs or biologics.
Conclusions:
- Liver enzyme abnormalities in PsA patients are linked to disease duration, diabetes mellitus, and NAFLD.
- Vigilant monitoring of liver function tests is vital for early detection and intervention in high-risk PsA populations.
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