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Targeted Cancer Therapies02:57

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The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
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Development of Sub-County Cancer Reporting Zones in Delaware and Example Use Case for Targeted Interventions.

Dawn Hollinger1, Sumitha Nagarajan2, Diane Ng3

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Summary
This summary is machine-generated.

Delaware Cancer Registry created 15 sub-county geographic zones for improved cancer reporting. These zones enable reliable cancer rates and targeted public health interventions.

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Area of Science:

  • Cancer surveillance and epidemiology
  • Geographic information systems (GIS) in public health
  • Population health and disparities research

Background:

  • Cancer registries are crucial for tracking disease patterns and informing public health strategies.
  • Sub-county level cancer data is essential for identifying localized trends and disparities.
  • The National Cancer Institute (NCI)/North American Association of Central Cancer Registries (NAACCR) Zone Design Project aims to standardize geographic units for cancer reporting.

Purpose of the Study:

  • To describe the Delaware Cancer Registry's (DCR) involvement in the NCI/NAACCR Zone Design Project.
  • To create optimized sub-county geographic areas (zones) for cancer reporting and geospatial analysis in Delaware.
  • To facilitate the use of zone-level data for targeted cancer interventions and public health outreach.

Main Methods:

  • Reviewed multiple zone configurations using AZTool, optimizing for population size, homogeneity (minority, poverty, urban), and compactness.
  • Conducted a stakeholder survey to gather input on preferred zone configurations for each county.
  • Utilized selected zones to calculate and map breast cancer incidence rates (overall and late-stage) by quintiles.

Main Results:

  • Established 15 zones across Delaware: 3 in Kent, 9 in New Castle, and 3 in Sussex County.
  • Zone populations ranged from 54,013 to 67,693.
  • Identified areas with higher late-stage breast cancer incidence, including regions near Wilmington, Middletown, and between Milford and Georgetown.

Conclusions:

  • Aggregating census tracts into zones enables reliable sub-county cancer rate reporting.
  • Zone-level cancer data provides meaningful insights into regional cancer trends for stakeholders and the public.
  • Delaware can leverage zone-level cancer information for targeted interventions and outreach initiatives.