miR-135b: An emerging player in cardio-cerebrovascular diseases

Area of Science:

• Biomedical Science
• Molecular Biology
• Cardiology
• Neurology

Background:

• MicroRNAs (miRNAs) are small non-coding RNAs that regulate gene expression.
• miR-135b is a conserved miRNA implicated in various physiological and pathological processes.
• Emerging evidence highlights miR-135b's significant role in cardio-cerebrovascular diseases.

Purpose of the Study:

• To comprehensively review the multifaceted role of miR-135b in cardio-cerebrovascular diseases.
• To elucidate the signaling pathways modulated by miR-135b in these pathologies.
• To discuss miR-135b as a potential therapeutic target and review related drug development and patents.

Main Methods:

• Literature review of preclinical and clinical studies on miR-135b.
• Analysis of signaling pathways involved in miR-135b-mediated disease processes.
• Survey of current therapeutic strategies and patents targeting miR-135b.

Main Results:

• miR-135b is a key regulator in myocardial infarction, cardiac hypertrophy, atherosclerosis, and neurodegenerative diseases like Parkinson's and Alzheimer's.
• Specific signaling pathways influenced by miR-135b in cardio-cerebrovascular diseases have been identified.
• Several drugs targeting miR-135b are under investigation, showing promise for therapeutic applications.

Conclusions:

• miR-135b is a critical molecular player in the pathogenesis of a wide spectrum of cardio-cerebrovascular diseases.
• Understanding miR-135b's mechanisms offers novel therapeutic avenues for treating these debilitating conditions.
• miR-135b represents a promising and important therapeutic target for future clinical interventions.