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Updated: Jun 14, 2025

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Published on: October 27, 2020
The paradoxical role of transforming growth factor-β in controlling oral squamous cell carcinoma development
Ruiting Peng1, Yun Huang1, Ping Huang1
1Department of Stomatology, The General Hospital of Western Theater Command PLA, Chengdu, China.
Abstract:
Transforming growth factor-β (TGF-β) is a multifunctional cytokine that plays a vital role in regulating cell growth, differentiation and survival in various tissues. It participates in a variety of cellular processes, including cell apoptosis, cell migration and evasion, and plays a paradoxical role in tumor genesis and development. In the early stage of tumor, TGF-β inhibits the occurrence of tumor by inhibiting cell proliferation and regulating cell apoptosis. In the advanced stage of tumor, TGF-β promotes tumor development and affects prognosis by promoting cell survival and proliferation, cell migration and invasion, participates in immune escape, etc. In this article, we will review the paradoxical role of TGF-β on the occurrence and development of oral squamous cell carcinoma.
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