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Expansion of Human Peripheral Blood γδ T Cells using Zoledronate
Published on: September 9, 2011
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Severe sepsis induced by zoledronic acid: A case report
1Department of Emergency Medicine, Chengdu Fifth People's Hospital, Chengdu, China.
Medicine
|August 30, 2024
Summary
Zoledronic acid, a common osteoporosis treatment, can rarely induce severe sepsis, particularly in immunocompromised patients. This case highlights the need for cautious monitoring of this serious adverse event.
Area of Science:
- Pharmacology
- Critical Care Medicine
- Rheumatology
Background:
- Zoledronic acid is a widely used bisphosphonate for osteoporosis.
- Severe sepsis induced by zoledronic acid has not been previously reported.
- This study presents the first documented case of severe sepsis linked to zoledronic acid.
Purpose of the Study:
- To report the first case of severe sepsis induced by zoledronic acid.
- To raise awareness among clinicians about this rare but serious adverse event.
- To emphasize the need for caution when prescribing zoledronic acid to potentially immunocompromised individuals.
Main Methods:
- A case report of a 58-year-old woman with osteoporosis and Behcet disease.
- The patient developed severe sepsis following zoledronic acid administration.
- Intensive care management including fluid resuscitation, vasopressors, antibiotics, and corticosteroids was initiated.
Main Results:
- The patient experienced severe sepsis, septic shock, and acute kidney injury.
- Treatment involved intensive care interventions to stabilize the patient.
- The patient was discharged with improvement and outpatient follow-up.
Conclusions:
- Severe sepsis is a rare but significant complication of zoledronic acid therapy.
- The exact mechanism of zoledronic acid-induced sepsis is unclear.
- Caution and close monitoring are advised when administering zoledronic acid, especially in patients with immunosuppression or underlying inflammatory conditions like Behcet disease.
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