Cyanobacterial biofilms: from natural systems to applications

Cyanobacteria are the ancestors of oxygenic photosynthesis. Fueled by light and water, their ability to reduce CO₂ to sugar holds potential for carbon-neutral production processes. Due to challenges connected to cultivation and engineering issues, cyanobiotechnology has yet to be able to establish itself broadly in industry. In recent years, applying cyanobacterial biofilms as whole-cell biocatalysts instead of suspension cultures has emerged as a novel concept to counteract low cell densities and low reaction stability, critical challenges in cyanobacterial applications. This review explores the potential of cyanobacterial biofilms for biotechnology and bioremediation. It briefly introduces cyanobacteria as primary producers in natural structured microbial communities; describes various applications in biotechnology and bioremediation; and discusses innovations, challenges, and future trends in this exciting research field.