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Updated: May 1, 2026
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A Thrombotic Stroke Model Based On Transient Cerebral Hypoxia-ischemia
Published on: August 18, 2015
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In-hospital recurrent stroke in ipsilateral carotid web patients undergoing thrombectomy
Farhan Khan1, Narendra Kala1, Kelvin Chang1
1Department of Neurology, Brown University, Providence, Rhode Island, USA.
Annals of Clinical and Translational Neurology
|August 31, 2024
Summary
Carotid artery webs, though rare, significantly increase the risk of early stroke recurrence in patients with large vessel occlusion. These findings highlight webs as an under-recognized cause of stroke, especially in younger individuals.
Area of Science:
- Neurology
- Vascular Medicine
- Stroke Research
Background:
- Carotid artery webs are a potential cause of ischemic stroke, particularly in younger patients without traditional risk factors.
- The immediate and long-term outcomes associated with carotid artery webs are not well-documented.
Purpose of the Study:
- To investigate the association between an ipsilateral carotid artery web and in-hospital stroke recurrence.
- To determine the risk of recurrent large vessel occlusion (LVO) in patients with carotid webs.
Main Methods:
- Analysis of adult patients admitted with acute anterior circulation large vessel occlusion (LVO) at a Comprehensive Stroke Center.
- Primary outcome: in-hospital stroke recurrence. Secondary outcome: in-hospital recurrent LVO.
- Multivariable logistic regression to assess the association between ipsilateral carotid web and stroke/LVO recurrence.
Main Results:
- 1.8% (27/1463) of patients with anterior circulation LVO had an ipsilateral carotid web.
- Patients with carotid webs were younger and less likely to be Caucasian.
- Carotid webs were associated with a significantly higher risk of recurrent ischemic stroke (aRR: 4.38) and recurrent ipsilateral LVO (aRR: 4.49).
Conclusions:
- Carotid webs are an under-recognized cause of acute LVO and are linked to an elevated risk of early recurrence.
- Further research is needed to confirm these findings and explore early revascularization strategies for symptomatic carotid artery webs.
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