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Updated: Jun 14, 2025

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Bergenin protects against osteoarthritis by inhibiting STAT3, NF-κB and Jun pathways and suppressing

Zhiwei Zhang1,2,3, Bo Li1,2,3, Shuqin Wu4

  • 1Department of Orthopedic Hospital, The 1st Affiliated Hospital, Jiangxi Medical College, Nanchang University, No. 17, Yongwaizheng Street, Nanchang, 330006, Jiangxi, China.

Scientific Reports
|August 31, 2024
PubMed

Insights

Bergenin (Ber) effectively treats osteoarthritis (OA) by reducing cartilage damage and inflammation. This study validates Ber

Area of Science:

  • Pharmacology
  • Biochemistry
  • Immunology

Background:

  • Osteoarthritis (OA) is a degenerative joint disease marked by cartilage breakdown.
  • Bergenin (Ber), a polyphenol, exhibits anti-inflammatory and antioxidant properties.
  • Ber's therapeutic potential for OA warrants investigation.

Purpose of the Study:

  • To evaluate Bergenin's efficacy in treating osteoarthritis.
  • To elucidate the underlying molecular mechanisms of Bergenin's action on OA through network pharmacology and experimental validation.

Main Methods:

  • Network pharmacology was employed to predict potential targets and pathways.
  • In vitro experiments assessed Bergenin's effects on chondrocytes and osteoclastogenesis.
  • In vivo studies utilized a DMM-induced mouse model of osteoarthritis.

Main Results:

  • Bergenin inhibited IL-1β-induced chondrocyte apoptosis and extracellular matrix degradation via STAT3, NF-κB, and Jun signaling pathways.
  • Bergenin suppressed osteoclast differentiation and osteoclast marker gene expression.
  • Bergenin treatment alleviated OA progression in a mouse model.

Conclusions:

  • Bergenin demonstrates significant protective effects against osteoarthritis progression.
  • Bergenin acts by modulating key inflammatory and signaling pathways involved in OA pathogenesis.
  • Bergenin shows promise as a potential therapeutic agent for osteoarthritis treatment.
Keywords:
BergeninJunNF-κBOsteoarthritisOsteoclastogenesisSTAT3

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