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Updated: Jun 14, 2025

Monitoring Protein Aggregation Kinetics In Vivo using Automated Inclusion Counting in Caenorhabditis elegans
Published on: December 17, 2021
[Neurofilament light chain and Polyglutamine disease]
Xiafei Long1, Zhao Chen, Hong Jiang
1Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China. jianghong73868@csu.edu.cn.
Abstract:
Polyglutamine (PolyQ) disease is a group of hereditary neurodegenerative diseases. It has become clear that brain damage may occur decades before the onset of symptoms. As a sensitive marker for neuro-axonal damages, neurofilament light chain (NfL) has appeared as a promising biomarker for neurological diseases. it may be used as a preclinical and clinical marker for the neurodegeneration in polyQ diseases, and is closely correlated with disease severity and progression, in particular different disease stages. This article has provided a review for the value of NfL as a biomarker in polyQ disease and its future research directions.
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