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In Vivo Inhibition of MicroRNA to Decrease Tumor Growth in Mice
Published on: August 23, 2019
[Retracted] miRNA‑490‑3p promotes the metastatic progression of invasive ductal carcinoma
1Department of Breast Medical Oncology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin's Clinical Research Center for Cancer, Key Laboratory of Breast Cancer Prevention and Therapy, Tianjin Medical University, Ministry of Education, Tianjin 300060, P.R. China.
Abstract:
Following the publication of this paper, it was drawn to the Editor's attention by a concerned reader that certain of the western blotting data shown in Fig. 2D, the cell migration and invasion assay data in Fig. 3C, the mouse imaging pictures in Fig. 4C and D, and the H&E‑stained images in Fig. 4E and F were strikingly similar to data appearing in different form in other articles written by different authors at different research institutes that had already been submitted or published elsewhere prior to the submission of this paper to Oncology Reports. Given that the abovementioned data had already apparently been submitted or published prior to the receipt of this paper at Oncology Reports, the Editor has decided that this paper should be retracted from the Journal. After having been in contact with the authors, they accepted the decision to retract the paper. The Editor apologizes to the readership for any inconvenience caused. [Oncology Reports 45: 706‑716, 2021; DOI: 10.3892/or.2020.7880].
Insights
This paper has been retracted due to concerns about duplicated data in western blotting, cell migration, invasion assays, and histology images. The findings were previously published elsewhere, leading to the retraction.
Area of Science:
- Oncology Research
- Biomedical Data Integrity
Context:
- Concerns raised by a reader regarding data duplication.
- Similar data appeared in previously published or submitted articles by different authors.
- The journal submission date was prior to the other publications.
Purpose:
- To address allegations of data duplication and plagiarism.
- To maintain scientific integrity and ethical publishing standards.
Summary:
- Western blotting, cell migration, invasion assay, and H&E-stained images showed striking similarities to previously published data.
- The data in question was submitted or published elsewhere before the current paper's submission.
- Retraction was decided due to the compromised integrity of the published findings.
Impact:
- Retraction of the paper to uphold scientific accuracy.
- Apology issued to the readership for the inconvenience caused by the duplicated data.
- Reinforces the importance of original research and data verification in scientific publications.

