Related Experiment Video
Updated: May 1, 2026
12:09
Patient-specific Modeling of the Heart: Estimation of Ventricular Fiber Orientations
Published on: January 8, 2013
13.6K
Three-Dimensional Heart Modeling of Hypertrophic Obstructive Cardiomyopathy for In Situ Patient-Specific Simulation
Karin C Smits1,2,3, Ron G H Speekenbrink1, Edsko E G Hekman2
1Department of Cardiothoracic Surgery, Thorax Centrum Twente, Medisch Spectrum Twente, Enschede, The Netherlands.
Innovations (Philadelphia, Pa.)
|September 2, 2024
Summary
Three-dimensional heart models created from cardiovascular magnetic resonance images improve surgical planning for hypertrophic obstructive cardiomyopathy (HOCM). These models enhance surgeon confidence and patient understanding, potentially reducing complications.
Area of Science:
- Cardiology
- Medical Imaging
- Biomedical Engineering
Background:
- Hypertrophic obstructive cardiomyopathy (HOCM) affects approximately 1 in 715 young adults.
- Septal myectomy is a treatment option for patients refractory to medical therapy.
- The complex cardiac anatomy in HOCM poses risks for serious complications during surgery, including ventricular septal defect and heart block.
Purpose of the Study:
- To evaluate the utility of cardiovascular magnetic resonance (CMR)-based 3-dimensional (3D) models in preoperative planning and training for HOCM septal myectomy.
- To assess the potential of these 3D models to decrease procedure-related complications and improve patient outcomes.
Main Methods:
- CMR images were utilized to segment cardiac structures and calculate left ventricular wall thickness.
- A 3D in silico model was created, with wall thickness exceeding 15 mm highlighted.
- A 3D-printed model was generated for surgical planning and patient counseling, with a silicone-filled portion for in situ simulation and perioperative quality control.
Main Results:
- Preoperative 3D in silico and 3D-printed heart models were successfully created for 5 HOCM patients.
- Since October 2020, the use of these models has led to increased surgeon preparedness, confidence, and decision-making ease.
- Patients reported feeling better informed about their condition and upcoming procedure.
Conclusions:
- 3D heart models derived from CMR data significantly optimize preoperative planning, surgical training, intraoperative quality control, and patient consultation for HOCM.
- Further research with larger patient cohorts is recommended to quantify the reduction in procedure-related complications and assess clinical outcomes.
Related Concept Videos
01:29Cardiomyopathy III: Hypertrophic Cardiomyopathy
805
Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
805
01:29Cardiomyopathy V: Interprofessional Care
753
Managing cardiomyopathy involves addressing underlying or precipitating causes, treating heart failure with medications, and implementing dietary changes and a balanced exercise and rest regimen.Lifestyle ModificationsCardiomyopathy patients should adopt a low-sodium diet to reduce fluid retention and manage heart failure. A personalized exercise and rest plan helps maintain physical fitness without overstraining the heart. Avoiding alcohol and tobacco is essential to prevent further damage to...
753