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Generation of Discriminative Human Monoclonal Antibodies from Rare Antigen-specific B Cells Circulating in Blood
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Generation of a highly specific and potent antibody against Ce-lamin/LMN-1
Adam Zahand1, Byron Williams1, Jun Liu1
1Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY, USA.
Micropublication Biology
|September 2, 2024
Abstract:
High quality antibodies are useful tools for research in cell and developmental biology. We have obtained highly specific and potent guinea pig-derived polyclonal antibodies against Ce-lamin/ LMN-1 . Western blotting experiments using these antibodies demonstrated that maternally loaded Ce-lamin/ LMN-1 protein is very stable, can perdure through embryonic and larval development and remain detectable in homozygous null lmn-1 mutant adults.

