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Updated: Jun 14, 2025

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Amantamide C, an Antitrypanosomal Linear Lipopeptide from a Marine Okeania sp. Cyanobacterium
Natsumi Watanabe1, Ghulam Jeelani2, Tomoyoshi Nozaki2
1Department of Applied Chemistry, Chuo University, 1-13-27 Kasuga, Bunkyo-ku, Tokyo 112-8551, Japan.
Abstract:
Amantamides are lipopeptides that act as selective CXC chemokine receptor 7 agonists and modulate spontaneous calcium oscillations in primary cultured neocortical neurons. We isolated a new analog of amantamides, amantamide C, from marine Okeania sp. cyanobacterium collected in Japan and established its structure based on NMR and MS/MS analyses, and degradation reactions. In addition, we evaluated the biological activity of amantamide C and revealed novel biological features of amantamide-type compounds.
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