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Platelet Indices and Hypertension: Results from Shahedieh Cohort Study, Yazd, Iran
Fateme Shakeri Shamsi1, Moslem Taheri Soodejani1
1Center for Healthcare Data Modeling, Departments of Biostatistics and Epidemiology, School of Public Health, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Insights
This study found that platelet indices like platelet distribution width (PDW) and platelet count (PLT) are associated with hypertension in adults. These findings may help in reducing the global burden of hypertension.
Area of Science:
- Cardiovascular Medicine
- Hematology
- Epidemiology
Background:
- Hypertension represents a significant global health challenge.
- Platelet indices are increasingly recognized as potential biomarkers for various diseases.
Purpose of the Study:
- To investigate the relationship between key platelet indices and the prevalence of hypertension.
- To explore how this relationship varies across different age groups.
Main Methods:
- A cross-sectional study involving 9448 participants aged 30-70 years.
- Assessment of hypertension status, platelet count (PLT), mean platelet volume (MPV), and platelet distribution width (PDW).
- Logistic regression analysis was employed to determine associations, controlling for factors like BMI and diabetes.
Main Results:
- Platelet distribution width (PDW) showed significant associations with hypertension across various age groups and quartiles.
- Platelet count (PLT) demonstrated a positive relationship with hypertension in specific age brackets (30-40 and 40-50 years) and quartiles.
- Adjusted odds ratios indicated varying degrees of association for different platelet indices and age demographics.
Conclusions:
- Certain platelet indices, including PDW and PLT, are correlated with hypertension.
- These findings suggest potential utility of platelet indices in hypertension risk assessment and management.
- Further research may elucidate the clinical application of these biomarkers to mitigate the impact of hypertension.
Introduction:
Hypertension is one of the most important diseases worldwide. In this study, we aim to demonstrate the relationship between platelet indices and hypertension.
Materials And Methods:
We studied 9448 people in the age range of 30 to 70 years. We assessed their hypertension status, platelet count (PLT), mean platelet volume (MPV), platelet distribution width (PDW), smoking, cardiovascular disease history, diabetes status, body mass index, and creatinine levels. Hypertension status was assessed qualitatively. All platelet indices were categorized by quartiles. We then used logistic regression to predict the relationship between these indices and hypertension.
Results:
PDW index and hypertension had a statistically significant relationship in the second quartile (16.2 fL < PDW ≤ 16.7 fL) in 30 to 40 years old (AOR: 0.225, 95% CI: 0.063-0.806), in the fourth quartile in 50 to 60 years old (AOR = 1.532, 95% CI: 1.048-2.238), and in all the quartiles of the age range of over 60 years. PLT index had a positive relationship (AOR = 3.147, 0.95% CI: 1.163-8.516) in 30 to 40 years old in the fourth quartile vs. the first quartile. A positive relationship was obtained in the third and fourth quartiles of PLT and the age range of 40 to 50 years, respectively (AOR = 2.063, 0.95% CI: 1.162-3.662) and (AOR = 2.204, 0.95% CI: 1.220-3.981).
Conclusion:
According to the results of this study, some platelet indices could be correlated with hypertension, so we may be able to reduce the burden of this disease.
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