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Detection of Invasive Pulmonary Aspergillosis in Haematological Malignancy Patients by using Lateral-flow Technology
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An account of the current status of point-of-care lateral flow tests for kidney biomarker detection

Tileshwar Sahare1, Badri Narayana Sahoo1, Surbhi Jaiswal1

  • 1Department of Biosciences and Biomedical Engineering, Indian Institute of Technology, Indore, Khandwa Road, Simrol, Indore - 453552, Madhya Pradesh, India. abhijeet.joshi@iiti.ac.in.

The Analyst
|September 2, 2024
PubMed

Insights

This review highlights lateral flow tests (LFTs) for detecting kidney disease biomarkers. These point-of-care biosensors offer a cost-effective, sensitive, and rapid method for diagnosing and monitoring conditions like acute kidney injury (AKI) and chronic kidney disease (CKD).

Area of Science:

  • Biomedical Engineering
  • Clinical Chemistry
  • Point-of-Care Diagnostics

Background:

  • Acute Kidney Injury (AKI) and Chronic Kidney Disease (CKD) are leading causes of global mortality and morbidity.
  • Non-invasive monitoring is crucial for managing chronic kidney diseases.
  • Biomarker detection offers significant potential for improving patient survival and reducing healthcare costs.

Purpose of the Study:

  • To review recent advancements in using lateral flow tests (LFTs) for renal biomarker detection.
  • To discuss challenges and opportunities in developing point-of-care (POC) diagnostic tools for kidney diseases.
  • To explore methods for enhancing the sensitivity of LFTs for improved diagnostic accuracy.

Main Methods:

  • Review of current literature on lateral flow test strip (LFT) technology for kidney disease biomarkers.
  • Analysis of different approaches for sensitivity enhancement in POC diagnostic devices.
  • Evaluation of ideal characteristics for point-of-care lateral flow tests, including cost-effectiveness, sensitivity, specificity, ease of use, and speed.

Main Results:

  • Lateral flow tests (LFTs) are identified as highly desirable point-of-care instruments for kidney disease diagnostics.
  • Recent developments show promise in improving the sensitivity and specificity of LFTs for biomarker detection.
  • The review details various strategies to enhance LFT performance for effective renal biomarker identification.

Conclusions:

  • LFTs represent a significant advancement in point-of-care diagnostics for kidney diseases, offering rapid and accessible testing.
  • Further research and development in sensitivity enhancement and quality control are crucial for optimizing LFTs.
  • Future advancements in POC and LFT kits hold the potential to revolutionize kidney disease management and patient outcomes.

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