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Comparative Analysis of Lower Limb Kinematics between the Initial and Terminal Phase of 5km Treadmill Running

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Time to cycle regularity and health risks.

Amna Naveed¹, Rachel Whooten

¹Division of Pediatric Endocrinology, Massachusetts General Hospital, Boston, Massachusetts, USA.

Current Opinion in Endocrinology, Diabetes, and Obesity

|September 2, 2024

Summary

Irregular menstrual cycles in adolescents may signal long-term health risks, including heart disease and cancer. Early intervention for delayed cycle regularity can improve adolescent health outcomes.

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Area of Science:

Reproductive endocrinology
Adolescent health
Public health

Background:

Menarche marks the onset of menstruation, but the reproductive axis requires time to mature, often resulting in irregular cycles during adolescence.
Delayed establishment of menstrual regularity is common but can be linked to significant health concerns.

Purpose of the Study:

To review the establishment of menstrual regularity in adolescents.
To explore health risks associated with prolonged time to cycle regularity.

Main Methods:

This review synthesizes findings from cross-sectional studies examining adolescent menstrual cycles.
Analysis focuses on associations between delayed cycle regularity and various health outcomes.

Main Results:

Prolonged time to menstrual cycle regularity in adolescents is linked to increased risks of ongoing menstrual dysfunction.
Associations were observed with cardiometabolic disorders, cancers, and overall mortality, independent of Polycystic Ovary Syndrome (PCOS) status in some cases.

Conclusions:

The menstrual cycle serves as a vital sign for adolescent health assessment.
Early intervention for adolescents with delayed menstrual regularity is crucial for mitigating future health risks.
Further longitudinal research is necessary to confirm causal relationships.