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Updated: Jul 20, 2026

Treatment of Ankle Osteoarthritis with Total Ankle Replacement Through a Lateral Transfibular Approach

Treatment of Ankle Osteoarthritis with Total Ankle Replacement Through a Lateral Transfibular Approach

Published on: January 24, 2018

Advanced therapies in orthopaedics.

Tobias Winkler^1,2,3, Sven Geissler^2,3, Tazio Maleitzke^3,4,5

¹Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Center for Musculoskeletal Surgery, Berlin, Germany.

EFORT Open Reviews

|September 2, 2024

Summary

Advanced therapies show promise for musculoskeletal repair but face clinical trial challenges. Understanding mechanisms and fostering strategic collaborations are key to overcoming roadblocks and advancing regenerative treatments.

Keywords:

advanced therapies biomaterials cell therapy degeneration gene therapy orthobiologics

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Area of Science:

Orthopaedics
Regenerative Medicine
Biotechnology

Background:

Advanced therapies are crucial for musculoskeletal tissue repair and regeneration.
Progress in orthopaedic advanced therapies lags behind other fields like oncology.
Current regenerative strategies often underperform in clinical trials.

Purpose of the Study:

To highlight the challenges in clinical translation of advanced therapies for musculoskeletal conditions.
To emphasize the need for a deeper understanding of therapeutic mechanisms.
To advocate for strategic research networks to accelerate clinical development.

Main Methods:

Literature review and analysis of current trends in regenerative orthopaedics.
Identification of key barriers in clinical trial progression.
Conceptual framework for strategic research network development.

Main Results:

Regenerative treatments in orthopaedics frequently fail to meet expectations in clinical trials.
A significant gap exists in understanding the mechanism of action for many investigated targets.
Existing research networks often lack essential commercial, regulatory, and reimbursement perspectives.

Conclusions:

Prioritizing mechanistic understanding before clinical trials is essential for advanced orthopaedic therapies.
Strategic research networks integrating scientific, commercial, and regulatory expertise are vital.
Overcoming clinical and patient-access roadblocks requires comprehensive, collaborative approaches.