Effects of nanoparticle deformability on multiscale biotransport

Area of Science:

• Biomedical Engineering
• Nanotechnology
• Drug Delivery

Background:

• Nanoparticle (NP) deformability is a key characteristic influencing drug delivery efficacy.
• Deformability impacts NP circulation, biodistribution, biological barrier penetration, and cellular interactions.
• Emerging research indicates roles in protein corona formation, intracellular trafficking, and organelle distribution.

Purpose of the Study:

• To review recent literature (past five years) on NP deformability and its impact on NP biotransport.
• To consolidate current understanding and identify consensus and discrepancies in findings.
• To provide a perspective on systematic investigation and future control of NP deformability for optimized drug delivery.

Main Methods:

• Literature review focusing on studies published within the last five years.
• Analysis of methods for modulating and evaluating NP deformability.
• Comparison of NP performance across various biotransport events.

Main Results:

• NP deformability significantly affects multiple stages of NP biotransport.
• Recent studies reveal NP deformability's influence on protein corona, intracellular trafficking, and organelle distribution.
• Discrepancies exist in current findings, necessitating further systematic investigation.

Conclusions:

• NP deformability is a critical, multifaceted factor in NP biotransport and drug delivery.
• Further research is required to fully elucidate and control NP deformability for enhanced therapeutic outcomes.
• Systematic investigation and advanced control strategies are crucial for optimizing NP-based drug delivery.