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The association between long noncoding RNA ABHD11-AS1 and malignancy prognosis: a meta-analysis
Guangyao Lin1, Tao Ye2, Jing Wang3
1Department of Gynecology, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, 200030, China.
BMC Cancer
|September 2, 2024
Summary
Elevated long non-coding RNA ABHD11-AS1 expression is linked to poorer cancer outcomes, including metastasis and advanced tumor stage. This suggests ABHD11-AS1 may serve as a valuable biomarker for cancer screening and prognosis prediction.
Area of Science:
- Oncology
- Molecular Biology
- Biomarker Discovery
Background:
- Long non-coding RNA ABHD11-AS1 is implicated in tumorigenesis, showing potential as a cancer biomarker and therapeutic target.
- Previous studies on ABHD11-AS1's role in malignancies have yielded conflicting results due to limited sample sizes.
- This meta-analysis aims to consolidate existing data to clarify the association between ABHD11-AS1 and various human cancers.
Purpose of the Study:
- To quantitatively assess the relationship between ABHD11-AS1 expression and the development and progression of human malignancies.
- To evaluate ABHD11-AS1 as a potential predictive biomarker for cancer prognosis.
Main Methods:
- A systematic literature search was conducted across eight databases up to January 1, 2024.
- Meta-analysis utilized odds ratios (ORs) and hazard ratios (HRs) with 95% confidence intervals (CIs) to determine significance.
- Subgroup, sensitivity, GEPIA2021, and UCSC Xena database analyses were performed to ensure result reliability and robustness.
Main Results:
- The meta-analysis included 14 studies with 1215 malignancy cases across eight cancer types.
- Increased ABHD11-AS1 expression significantly correlated with lymph node metastasis (OR=2.73), advanced tumor stage (OR=3.14), and unfavorable overall survival (HR=1.81).
- External validation confirmed elevated ABHD11-AS1 in eight malignancies and its association with poor prognosis (PFI, DFI, DSS, OS).
Conclusions:
- Elevated ABHD11-AS1 expression is strongly associated with poorer cancer prognosis.
- ABHD11-AS1 shows promise as a biomarker for cancer screening and predicting patient outcomes.
- Further large-scale, multi-center studies with standardized protocols are needed to validate these findings.
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