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An Orthotopic Bladder Cancer Model for Gene Delivery Studies
Published on: December 1, 2013
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Bladder sparing options for muscle-invasive bladder cancer.
Ekaterina Laukhtina1, Marco Moschini2, Jeremy Yuen-Chun Teoh3
1Department of Urology, Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria.
Current Opinion in Urology
|September 3, 2024
Summary
Bladder-sparing treatments offer a promising alternative to radical cystectomy for select muscle-invasive bladder cancer (MIBC) patients. Research is advancing treatment protocols and patient selection for improved quality of life.
Area of Science:
- Urology
- Oncology
Background:
- Muscle-invasive bladder cancer (MIBC) traditionally requires radical cystectomy (RC).
- Bladder preservation strategies are emerging as alternatives for select patients.
Purpose of the Study:
- Critically evaluate current bladder-sparing options for MIBC.
- Provide an overview of future research directions in bladder preservation.
Main Methods:
- Review of current literature on bladder-sparing treatments for MIBC.
- Analysis of outcomes for trimodal therapy (TMT) and combination approaches.
Main Results:
- Bladder-sparing treatments, including TMT, show comparable outcomes to RC in well-selected MIBC patients.
- Combining immunotherapy with conventional treatments yields promising results.
- Ongoing research focuses on optimizing protocols, drug delivery, and biomarkers for response assessment.
Conclusions:
- Bladder preservation offers a viable alternative to RC for selected MIBC patients, potentially improving quality of life.
- Optimizing patient selection, response assessment, and salvage strategies are crucial.
- The role of bladder preservation in MIBC is expected to expand with evolving evidence.
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