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Updated: Jun 14, 2025

Vessel-Sparing Microsurgical Longitudinal Intussusception Vasoepididymostomy to Treat Epididymal Obstructive Azoospermia
Published on: May 27, 2022
Epigenetics of nonobstructive azoospermia
Sezgin Gunes1, Asli Metin Mahmutoglu2, Neslihan Hekim1
1Department of Medical Biology, Medical Faculty, Ondokuz Mayis University, Samsun 55139, Türkiye.
Abstract:
Nonobstructive azoospermia (NOA) is a severe and heterogeneous form of male factor infertility caused by dysfunction of spermatogenesis. Although various factors are well defined in the disruption of spermatogenesis, not all aspects due to the heterogeneity of the disorder have been determined yet. In this review, we focus on the recent findings and summarize the current data on epigenetic mechanisms such as DNA methylation and different metabolites produced during methylation and demethylation and various types of small noncoding RNAs involved in the pathogenesis of different groups of NOA.
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