Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Nondisjunction01:21

Nondisjunction

3.8K
Nondisjunction is the failure of homologous chromosomes or sister chromatids to separate correctly and move to the opposite poles of the cells. This produces daughter cells with abnormal chromosome numbers.  Nondisjunction is common during anaphase I or anaphase II of meiosis.  Mutations in synaptonemal complex proteins that attach homologous chromosomes increase the chances of nondisjunction in anaphase I of meiosis I. In contrast, mutations in topoisomerases and condensins that hold...
3.8K
Genomic Imprinting and Inheritance02:30

Genomic Imprinting and Inheritance

34.2K
Diploid organisms inherit genetic material through chromosomes from both parents. Copies of the same gene are known as alleles. In most cases, both alleles are simultaneously expressed and allow various cellular processes to function optimally. If one of the alleles is missing or mutated, the expression of the other allele can compensate; however, this is not true for all genes.
The expression of some genes depends on which parent passed the gene to the offspring, through a phenomenon known as...
34.2K
Infertility in Males01:23

Infertility in Males

255
Male infertility affects millions of couples worldwide, arising from various factors that impact different stages of the reproductive process. An endocrine imbalance resulting from conditions like hypogonadism, Klinefelter syndrome, or pituitary disorders can disrupt hormone levels and reduce sperm production. Testicular defects, such as tumors, cryptorchidism, atrophic testes, abnormal sperm morphology, and low sperm count or motility, may arise due to genetic factors, structural...
255
Spermatogenesis01:41

Spermatogenesis

102.3K
Spermatogenesis is the process by which haploid sperm cells are produced in the male testes. It starts with stem cells located close to the outer rim of seminiferous tubules. These spermatogonial stem cells divide asymmetrically to give rise to additional stem cells (meaning that these structures “self-renew”), as well as sperm progenitors, called spermatocytes. Importantly, this method of asymmetric mitotic division maintains a population of spermatogonial stem cells in the male...
102.3K
Meiosis I03:09

Meiosis I

40.1K
Meiosis is the division of a diploid cell into haploid cells forming sperm and eggs in animals through differentiation. Meiosis I is the first stage of meiosis, where the genetic recombination of homologous chromosomes and the reduction of the ploidy level by half occurs.
Prophase I is the most extended and complex step of meiosis I characterized by synapsis, chromosome pairing, and recombination of the homologous chromosomes. This process is facilitated by a proteinaceous structure called the...
40.1K
Oogenesis02:07

Oogenesis

63.5K
In human women, oogenesis produces one mature egg cell or ovum for every precursor cell that enters meiosis. This process differs in two unique ways from the equivalent procedure of spermatogenesis in males. First, meiotic divisions during oogenesis are asymmetric, meaning that a large oocyte (containing most of the cytoplasm) and minor polar body are produced as a result of meiosis I, and again following meiosis II. Since only oocytes will go on to form embryos if fertilized, this unequal...
63.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Induced Pluripotent Stem Cells and the Future of Male Infertility: A Translational Perspective.

Stem cell reviews and reports·2026
Same author

Association of CXCR7 and CXCR4 expression with tumor immune phenotypes in tubo-ovarian high-grade serous carcinoma.

Irish journal of medical science·2026
Same author

Revolutionizing Male Infertility Care: Emerging Technologies and Future Clinical Directions.

The world journal of men's health·2026
Same author

Copper, cuproptosis and male reproductive health: An updated and narrative review.

Reproductive toxicology (Elmsford, N.Y.)·2026
Same author

Authorship Accountability and Transparency: A Standardized Model from the Global Andrology Forum.

The world journal of men's health·2026
Same author

Comparative miRNA Expression Profiling Reveals Candidates Involved in Prostate Cancer Radioresistance.

APMIS : acta pathologica, microbiologica, et immunologica Scandinavica·2026

Related Experiment Video

Updated: Jun 14, 2025

Vessel-Sparing Microsurgical Longitudinal Intussusception Vasoepididymostomy to Treat Epididymal Obstructive Azoospermia
06:28

Vessel-Sparing Microsurgical Longitudinal Intussusception Vasoepididymostomy to Treat Epididymal Obstructive Azoospermia

Published on: May 27, 2022

3.7K

Epigenetics of nonobstructive azoospermia.

Sezgin Gunes1, Asli Metin Mahmutoglu2, Neslihan Hekim1

  • 1Department of Medical Biology, Medical Faculty, Ondokuz Mayis University, Samsun 55139, Türkiye.

Asian Journal of Andrology
|September 3, 2024
PubMed
Summary
This summary is machine-generated.

Nonobstructive azoospermia (NOA) is a severe male infertility cause. This review explores epigenetic factors like DNA methylation and noncoding RNAs in NOA pathogenesis, offering new insights into its complex origins.

Keywords:
DNA methylationepigeneticshistone modificationsnoncoding RNAsnonobstructive azoospermia

More Related Videos

Using Mouse Oocytes to Assess Human Gene Function During Meiosis I
11:13

Using Mouse Oocytes to Assess Human Gene Function During Meiosis I

Published on: April 10, 2018

8.8K
Analysis of Chromosome Segregation, Histone Acetylation, and Spindle Morphology in Horse Oocytes
12:11

Analysis of Chromosome Segregation, Histone Acetylation, and Spindle Morphology in Horse Oocytes

Published on: May 11, 2017

10.9K

Related Experiment Videos

Last Updated: Jun 14, 2025

Vessel-Sparing Microsurgical Longitudinal Intussusception Vasoepididymostomy to Treat Epididymal Obstructive Azoospermia
06:28

Vessel-Sparing Microsurgical Longitudinal Intussusception Vasoepididymostomy to Treat Epididymal Obstructive Azoospermia

Published on: May 27, 2022

3.7K
Using Mouse Oocytes to Assess Human Gene Function During Meiosis I
11:13

Using Mouse Oocytes to Assess Human Gene Function During Meiosis I

Published on: April 10, 2018

8.8K
Analysis of Chromosome Segregation, Histone Acetylation, and Spindle Morphology in Horse Oocytes
12:11

Analysis of Chromosome Segregation, Histone Acetylation, and Spindle Morphology in Horse Oocytes

Published on: May 11, 2017

10.9K

Area of Science:

  • Reproductive Biology
  • Genetics
  • Epigenetics

Background:

  • Nonobstructive azoospermia (NOA) represents a significant and diverse cause of male infertility, stemming from spermatogenesis dysfunction.
  • While numerous factors contributing to spermatogenesis disruption are known, the full spectrum of causes, particularly those related to NOA's heterogeneity, remains incompletely understood.

Purpose of the Study:

  • To review recent findings on epigenetic mechanisms in nonobstructive azoospermia.
  • To summarize current data on DNA methylation, related metabolites, and small noncoding RNAs in NOA pathogenesis.

Main Methods:

  • Literature review focusing on recent scientific findings.
  • Analysis of data concerning epigenetic modifications and noncoding RNAs.
  • Synthesis of information on the role of these factors in different NOA groups.

Main Results:

  • Epigenetic alterations, including DNA methylation patterns and metabolites, are implicated in NOA.
  • Various small noncoding RNAs play a role in the pathogenesis of distinct NOA subgroups.
  • These epigenetic factors contribute to the heterogeneity observed in nonobstructive azoospermia.

Conclusions:

  • Epigenetic mechanisms are crucial in understanding the pathogenesis of nonobstructive azoospermia.
  • Further research into DNA methylation and noncoding RNAs may elucidate NOA's complex etiology.
  • Targeting epigenetic pathways could offer future therapeutic strategies for male infertility.