Related Experiment Video

Updated: Jun 14, 2025

Identifying Coronary Artery Calcification on Non-gated Computed Tomography Scans
04:40

Identifying Coronary Artery Calcification on Non-gated Computed Tomography Scans

Published on: August 28, 2018

15.1K

Is cardiac function associated with the clinical course of disease in patients with gout? A prospective study

Yanni Dong1, Yiming Li2, Caijie Liu1

  • 1Department of Medical Ultrasonics, First Affiliated Hospital of Jinzhou Medical University, Jinzhou, China.

Echocardiography (Mount Kisco, N.Y.)
|September 3, 2024
PubMed

Insights

Gout disease duration impacts left heart function. Elevated uric acid independently predicts reduced left ventricular global longitudinal strain (LVGLS) in gout patients, affecting atrial function.

Area of Science:

  • Cardiology
  • Rheumatology
  • Medical Science

Background:

  • Gout is a common inflammatory arthritis characterized by hyperuricemia.
  • Left heart dysfunction can be a complication of chronic inflammatory diseases.
  • Understanding the impact of gout duration on cardiac function is crucial for patient management.

Purpose of the Study:

  • To investigate left heart function in gout patients with varying disease durations.
  • To identify independent factors influencing left heart functional changes.
  • To explore interactions between left atrial and left ventricular functions.

Main Methods:

  • A cohort of 171 gout patients was divided into two groups based on disease duration (<10 years and ≥10 years).
  • A control group of 94 healthy volunteers was included for comparison.
  • Cardiac strain parameters were assessed, and multivariate logistic regression was used to identify predictors of left ventricular global longitudinal strain (LVGLS).

Main Results:

  • Significant differences in cardiac strain parameters were observed between gout patients and controls, diminishing with disease progression.
  • Uric acid was identified as an independent predictor of decreased LVGLS.
  • LVGLS positively correlated with left atrial systolic rate (LASr) and left atrial systolic contraction time (LASct).

Conclusions:

  • The duration of gout significantly influences left heart function.
  • Uric acid is a key independent predictor of reduced LVGLS in gout patients.
  • These findings highlight the importance of monitoring cardiac function in gout management.
Abstract

Keywords:
goutleft atriumleft ventriclestrainuric acid

More Related Videos

An Immunohistopathologic Study to Profile the Folate Receptor Beta Macrophage and Vascular Immune Microenvironment in Giant Cell Arteritis06:35

An Immunohistopathologic Study to Profile the Folate Receptor Beta Macrophage and Vascular Immune Microenvironment in Giant Cell Arteritis

Published on: February 8, 2019

7.2K
Glycemic Impact on Knee Osteoarthritis Symptoms on Physical, Radiographic, and Inflammatory Markers among Individuals Aged 50 and Over with Diabetes07:22

Glycemic Impact on Knee Osteoarthritis Symptoms on Physical, Radiographic, and Inflammatory Markers among Individuals Aged 50 and Over with Diabetes

Published on: March 7, 2025

210

Related Concept Videos

Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers01:19

Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers

Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
68
Pathophysiology of Heart Failure01:17

Pathophysiology of Heart Failure

Heart failure (HF) is a progressive syndrome involving ventricles that leads to inadequate cardiac output. It can be classified based on location and output or ejection fraction. Ejection fraction (EF) is an essential measurement in the diagnosis and surveillance of HF. Reduced EF corresponds to systolic heart failure (HFrEF). However, HF with preserved ejection fraction (HFpEF) is becoming increasingly prevalent. Also known as diastolic HF, this form of HF is related to aging. The...
1.5K
Assessment of the Cardiovascular System I: Subjective Data01:23

Assessment of the Cardiovascular System I: Subjective Data

A thorough health history and physical assessment are essential for identifying cardiovascular disease (CVD) symptoms and distinguishing them from other health issues.
Initial Enquiry
Ask the patient about their primary concern and thoroughly explore all reported symptoms.
Medical History
Investigate past illnesses affecting the cardiovascular system, such as angina, anemia, rheumatic fever, congenital heart disease, stroke, thrombophlebitis, dysrhythmias, varicosities
Inquire about symptoms...
291
Blood Studies for Cardiovascular System I: Cardiac Biomarkers01:20

Blood Studies for Cardiovascular System I: Cardiac Biomarkers

Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
119
Imbalances in Cardiac Output01:26

Imbalances in Cardiac Output

The heart's primary function is to pump blood throughout the body, maintaining a balance between blood sent out (cardiac output) and blood returning (venous return). If this balance is disrupted, it can result in congestive heart failure (CHF), a severe condition where the heart becomes an inefficient pump, leading to inadequate blood circulation.
CHF can occur due to the failure of either side of the heart. Left-side failure leads to pulmonary congestion—the right side continues to send...
1.4K
Exercise and Cardiovascular Response01:20

Exercise and Cardiovascular Response

Exercise significantly impacts cardiovascular response, which is crucial for understanding patient health and designing effective treatment plans.
Light to moderate physical activity initiates a series of interconnected responses in the body. The heart rate modestly increases in anticipation of the workout, followed by widespread vasodilation as oxygen consumption by skeletal muscles increases. This results in decreased peripheral resistance, increased capillary blood flow, and accelerated...
750