Related Experiment Video
Updated: Jun 14, 2025

In Vivo Mouse Model of Spinal Implant Infection
Published on: June 23, 2020
Extended Postoperative Antibiotic Prophylaxis Is Associated with No Clinical Value and Higher Projected Cost
Mohamed E Awad1, Nicole A Griffin, Aaron B Epperson
1Orthopedics Department, University of Colorado Anschutz Medical Campus, Aurora, Colorado.
None:
» We aimed to determine the cost-effectiveness of different protocols of extended postoperative antibiotic prophylaxis (E-PAP) following adult spinal surgery.
None:
» Both stratified (randomized controlled trials only) and nonstratified (all studies) analyses demonstrated that E-PAP has no significant value in reducing the rate of surgical site infection (SSI), deep SSI, or superficial SSI.
None:
» Notably, the E-PAP protocols were associated with a significant increase in the length of hospital stay, resulting in an additional expenditure of $244.4 per episode for the E-PAP 72 hours protocol compared with PAP 24 hours and $309.8 per episode for the E-PAP >48 hours protocol compared with PAP <48 hours.
None:
» E-PAP does not demonstrate any significant reduction in the rate of SSIs following spine surgery. However, these extended protocols were significantly associated with an increase in the length of hospital stay and higher overall projected costs.
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