Hypertrophic foci of pancreatic acinar cells in rats

A morphologically distinctive type of pancreatic acinar cell foci, different from hyperplastic nodules and adenomas, in rats has been recognized for two decades. The lesions have been observed to occur spontaneously and to be induced experimentally. They consist of enlarged acinar cells with abundant cytoplasm of altered staining characteristics and prominent nuclei. There is, however, a wide divergence of opinion among investigators regarding the nature of the lesions. As a result of different interpretations and classifications, many terms have been given to them. Based on morphologic characteristics, the author has designated the lesions as hypertrophic foci, a descriptive morphological term. The biologic significance with particular reference to age and the relationship with acinar cell neoplasia is discussed. Also included in the review are similar lesions in other rodent species.