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Updated: Jun 14, 2025
06:46
Competing-Risk Nomogram for Predicting Cancer-Specific Survival in Multiple Primary Colorectal Cancer Patients after Surgery
Published on: September 27, 2024
229
Vulvar Paget's disease: A population-based cancer registry descriptive study
Charlée Nardin1, Pauline Fattet2, Rajeev Ramanah2
1Department of Dermatology, University Hospital, Besançon, France; Inserm 1098 RIGHT, University of Franche Comté, Besançon, France.
Journal of Gynecology Obstetrics and Human Reproduction
|September 3, 2024
Summary
Vulvar Paget's Disease (VPD) frequently recurs, especially after 5 years. Adjuvant therapy after surgery significantly improves recurrence-free survival for this rare skin cancer.
Area of Science:
- Dermatology
- Oncology
- Epidemiology
Background:
- Vulvar Paget's Disease (VPD) is a rare skin cancer.
- While prognosis is generally good, high recurrence rates negatively impact quality of life.
Purpose of the Study:
- To investigate the epidemiological and clinical characteristics of VPD.
- Focus on diagnoses within the Franche Comté region of France.
Main Methods:
- Retrospective study of VPD cases diagnosed between 1981 and 2021.
- Inclusion of data from the Doubs cancer registry.
- Analysis of clinical, histological, therapeutic, and follow-up data.
Main Results:
- 21 patients diagnosed with VPD (19 intra-epithelial, 2 invasive).
- Median age at diagnosis was 72 years; median time to diagnosis was 24 months.
- Associated cancers found in 29% of patients.
- 5-year recurrence rate was 26%, increasing to 42% at longer follow-up.
- Incomplete surgical resection (100%) was linked to 86% recurrence, versus 20% with topical treatment.
- Postoperative adjuvant therapy significantly improved recurrence-free survival (p < 0.001).
Conclusions:
- Postoperative recurrence of VPD is common, often occurring after 5 years.
- Prolonged patient follow-up is essential.
- Adjuvant treatment post-surgery significantly enhances recurrence-free survival.
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