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Physiologic consequences of status epilepticus.

R P Simon

    Epilepsia
    |January 1, 1985
    PubMed
    Summary
    This summary is machine-generated.

    Status epilepticus, a prolonged seizure, causes central nervous system damage and significant physiological changes. These changes, including fever and acidosis, can mislead treatment and lead to complications like sudden death.

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    Area of Science:

    • Neurology
    • Critical Care Medicine
    • Pathophysiology

    Background:

    • Prolonged seizures, or status epilepticus, can lead to irreversible central nervous system damage.
    • The physiological changes during status epilepticus can complicate patient management and treatment decisions.
    • Understanding these changes is crucial for effective clinical intervention.

    Purpose of the Study:

    • To outline the significant physiological consequences of status epilepticus.
    • To highlight how these changes can impact patient outcomes and therapeutic strategies.
    • To emphasize the potential for severe complications arising from status epilepticus.

    Main Methods:

    • Review of existing literature on the pathophysiology of status epilepticus.
    • Analysis of physiological parameters commonly observed during prolonged seizures.

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  • Correlation of physiological changes with potential clinical outcomes.

    • Main Results:

    • Status epilepticus is associated with elevated body temperature and increased peripheral white blood cell count.
    • Transient spinal fluid pleocytosis, marked metabolic acidosis, and elevated plasma hormone concentrations are routinely observed.
    • Epinephrine levels can reach arrhythmogenic ranges, and significant pressure fluctuations in pulmonary and systemic circulations may cause pulmonary edema.

    Conclusions:

    • The physiological disturbances during status epilepticus are profound and can exacerbate neurological damage.
    • These changes necessitate careful monitoring and can mislead therapeutic decisions.
    • Complications such as cardiac arrhythmias and pulmonary edema are significant risks associated with status epilepticus.