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Related Experiment Video

Updated: Jun 14, 2025

A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer

A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer

Published on: March 6, 2018

Divergent Evolution in Bilateral Prostate Cancer: a Case Study.

Roni Haas^1,2,3,4, Yash Patel^1,2,3,4, Lydia Y Liu^1,2,3,4

¹Department of Human Genetics, University of California, Los Angeles, USA.

Medrxiv : the Preprint Server for Health Sciences

|September 4, 2024

Summary

This summary is machine-generated.

Multifocal prostate cancer can arise from independent origins, not just clonal expansion. Genomic analysis reveals distinct tumors, aiding accurate diagnosis and patient management.

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Published on: September 18, 2018

Area of Science:

Oncology
Genomics
Urology

Background:

Multifocal prostate cancer is common but often lacks genomic characterization.
Distinguishing between clonal and independent tumors is crucial for patient management.

Purpose of the Study:

To investigate the genomic landscape of multifocal prostate cancer.
To determine if distinct lesions represent clonal evolution or independent primaries.

Main Methods:

Whole-genome sequencing of bilateral prostate cancer lesions.
Analysis of distinct driver copy number alteration (CNA) regions.

Main Results:

Identified two somatically unrelated tumors with distinct driver CNA regions.
Demonstrated independent origins for clinically similar multifocal tumors.

Conclusions:

Clinically indistinguishable multifocal tumors can be independent cancers.
Genomic prognostics are essential to prevent mischaracterization and guide treatment.