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Updated: Jun 14, 2025

Enzymatic Cascade Reactions for the Synthesis of Chiral Amino Alcohols from L-lysine
Published on: February 16, 2018
Optical Enantiodifferentiation of Chiral Nitriles
Jeffrey S S K Formen1, Christian Wolf1
1Chemistry Department, Georgetown University, Washington D.C. 20057, United States.
Abstract:
Chiroptical sensing of nitriles is achieved with excellent functional group tolerance by hydrozirconation and subsequent transmetalation of the corresponding iminate to a chromophoric palladium complex. A one-pot workflow that uses the Schwartz reagent and [(η3-1-tert-butylindenyl)(μ-Cl)Pd]2 as sensor generates a palladium complex displaying red-shifted CD inductions and characteristic UV changes. These chiroptical responses are accurately correlated to the enantiomeric ratio and total concentration of the original nitrile.
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