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Published on: November 22, 2015
Five Undescribed Sesquiterpenes with Anti-Inflammasome Activity Isolated from Saussurea Laniceps
Xuedan Zu1, Ling Ding1, Bowen Zheng2
1Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, Yunnan Characteristic Plant Extraction Laboratory, Yunnan Provincial Center for Research & Development of Natural Products, State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan, Yunnan University, School of Pharmacy, School of Medicine, School of Chemical Science and Technology, Yunnan University, Kunming, 650500, P. R. China.
Abstract:
Five previously undescribed guaialactone-type sesquiterpenes (1-5), called Lanicepsmines A-E, along with eleven know compounds (6-16), were isolated from the whole plant of Saussurea laniceps. NMR spectroscopic data analysis and MASS permitted the definition of their structures. The stereochemistry of the compounds was confirmed by ECD calculations. It is worth noting that compound 1 and 2 contain amino groups. Part of compounds were tested the anti-inflammasome activity, and compound 14 exhibited potent activity and decreased LDH level in a dose-dependent manner, with IC50 values of 0.698 μM.
