Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Nephrons01:10

Nephrons

2.2K
The kidneys are intricate organs with millions of working units known as nephrons. Each nephron features two major structures: the renal corpuscle, which facilitates blood plasma filtration, and the renal tubule, which handles the glomerular filtrate. Blood supply is directly linked to the nephrons. The renal corpuscle consists of the glomerulus, a capillary network, and the Bowman's capsule, a double-walled epithelial structure that encases the glomerulus. The filtering of blood plasma...
2.2K
Disorders of the Urinary System01:20

Disorders of the Urinary System

266
The urinary system is responsible for eliminating waste and excess fluids from the body. However, disorders of the urinary system can arise due to various reasons like infections, stress, age, congenital abnormalities, and lifestyle.
Urinary tract infections (UTIs) are one of the most common urinary system disorders. They are caused by bacteria that enter the urethra and can spread to the bladder resulting in cystitis. Pyelonephritis is the result of a UTI that has ascended to the level of the...
266
Renal Tubule and Collecting Duct01:24

Renal Tubule and Collecting Duct

864
The renal tubule is divided into three parts: the proximal convoluted tubule (PCT), the Loop of Henle (LOH), and the distal convoluted tubule (DCT).
Proximal Convoluted Tubule (PCT):
The PCT is the initial segment of the renal tubule, extending from the Bowman's capsule that encloses the glomerulus. Its convoluted structure and microvilli-lined cells increase the surface area for reabsorption. The PCT reabsorbs glucose, amino acids, sodium, and water from the filtrate, ensuring essential...
864
Renal Corpuscle01:20

Renal Corpuscle

1.8K
The glomerulus and Bowman's capsule are two essential components of the nephron, which is the functional unit of the kidney. These microscopic structures play a critical role in the process of blood filtration to produce urine.
Glomerulus: Structure and Function
The glomerulus is a tiny, intricate network of capillaries located at the beginning of the nephron. It's enveloped by the Bowman's capsule and receives its blood supply from an afferent arteriole, which divides into numerous...
1.8K
Disorders of Hemostasis01:24

Disorders of Hemostasis

754
Hemostasis, the process that stops bleeding after a blood vessel injury, is crucial for maintaining the integrity of the circulatory system. However, disorders of hemostasis can disrupt this delicate balance, leading to either excessive clotting or bleeding. These disorders can be broadly classified into thromboembolic disorders and bleeding disorders.
Thromboembolic Disorders
Two factors primarily cause thromboembolic conditions.
754
Dialysis01:27

Dialysis

277
Renal failure occurs when the kidneys lose their ability to filter waste products from the blood effectively. It can be classified into two types: acute renal failure (ARF) and chronic renal failure (CRF).
Acute kidney injury develops suddenly and can be caused by pre-renal causes (e.g., hypovolemia, shock), intrinsic renal causes (e.g., acute tubular necrosis), or post-renal causes (e.g., urinary obstruction). In contrast, chronic renal failure progresses gradually over time and is often...
277

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Predictors of Telehealth Use Among Cancer Survivors: Retrospective Study.

JMIR cancer·2026
Same author

Brief Report: Real-World Outcomes in Patients Living With Human Immunodeficiency Virus and Lung Cancer Treated With Immune Checkpoint Inhibitors.

JTO clinical and research reports·2026
Same author

Splitpea: a Python package for protein-protein interaction network rewiring analysis due to alternative splicing.

Bioinformatics (Oxford, England)·2026
Same author

Cancer support in the era of virtual interaction: analysis of a community-based cancer support organization.

Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer·2025
Same author

REFINE: a database of linked clinical data and genomic biomarkers in renal cell carcinoma patients receiving immunotherapy-based treatment regimens.

The oncologist·2025
Same author

Pulmonary Rehabilitation in Patients with Operable Non-Small Cell Lung Cancer.

Journal of clinical medicine·2025

Related Experiment Video

Updated: Jun 14, 2025

A High-throughput Assay to Assess and Quantify Neutrophil Extracellular Trap Formation
09:59

A High-throughput Assay to Assess and Quantify Neutrophil Extracellular Trap Formation

Published on: January 29, 2019

10.0K

Extreme Reactive Thrombocytosis Caused by Obstructive Nephrolithiasis and Pyelonephritis.

Jeffrey Zhong1, Clifford D Packer2

  • 1Case Western Reserve University School of Medicine, Cleveland, Ohio, USA.

Clinical Medicine & Research
|September 4, 2024
PubMed
Summary

Reactive thrombocytosis, often below 1000 × 109/L, can exceed this in rare cases, as seen with a urinary tract infection. Markedly elevated platelets may signal obstructive uropathy.

Keywords:
GeriatricsHematologyObstructive uropathyReactive thrombocytosisUrinary tract infection

More Related Videos

Real-time Imaging of Heterotypic Platelet-neutrophil Interactions on the Activated Endothelium During Vascular Inflammation and Thrombus Formation in Live Mice
11:18

Real-time Imaging of Heterotypic Platelet-neutrophil Interactions on the Activated Endothelium During Vascular Inflammation and Thrombus Formation in Live Mice

Published on: April 2, 2013

15.7K
Comprehensive Analysis of Procoagulant Platelets Exhibiting Features of Necrosis, Apoptosis and Platelet Activation
04:37

Comprehensive Analysis of Procoagulant Platelets Exhibiting Features of Necrosis, Apoptosis and Platelet Activation

Published on: May 23, 2025

239

Related Experiment Videos

Last Updated: Jun 14, 2025

A High-throughput Assay to Assess and Quantify Neutrophil Extracellular Trap Formation
09:59

A High-throughput Assay to Assess and Quantify Neutrophil Extracellular Trap Formation

Published on: January 29, 2019

10.0K
Real-time Imaging of Heterotypic Platelet-neutrophil Interactions on the Activated Endothelium During Vascular Inflammation and Thrombus Formation in Live Mice
11:18

Real-time Imaging of Heterotypic Platelet-neutrophil Interactions on the Activated Endothelium During Vascular Inflammation and Thrombus Formation in Live Mice

Published on: April 2, 2013

15.7K
Comprehensive Analysis of Procoagulant Platelets Exhibiting Features of Necrosis, Apoptosis and Platelet Activation
04:37

Comprehensive Analysis of Procoagulant Platelets Exhibiting Features of Necrosis, Apoptosis and Platelet Activation

Published on: May 23, 2025

239

Area of Science:

  • Hematology
  • Nephrology
  • Internal Medicine

Background:

  • Reactive thrombocytosis typically presents with platelet counts below 1000 × 109/L.
  • Elevated platelet counts can be associated with various underlying conditions, including infections and inflammatory processes.
  • Distinguishing reactive thrombocytosis from myeloproliferative neoplasms is crucial for appropriate patient management.

Purpose of the Study:

  • To report a rare case of reactive thrombocytosis exceeding 1000 × 109/L.
  • To highlight the association between markedly elevated platelet counts, urinary tract infections, and obstructive uropathy.
  • To increase physician awareness of atypical presentations of reactive thrombocytosis.

Main Methods:

  • Case report of an 80-year-old male with rheumatoid arthritis and incidental thrombocytosis.
  • Diagnostic work-up including laboratory testing for infections and myeloproliferative disorders.
  • Clinical management involving antibiotics and ureteral stent placement for obstructive nephrolithiasis and pyelonephritis.

Main Results:

  • The patient presented with a platelet count of 1011 × 109/L and subsequent leukocytosis.
  • Negative results for JAK-2V617F mutation, BCR-ABL, and myeloproliferative neoplasms (MPL/CALR).
  • Thrombocytosis and leukocytosis resolved with treatment for pyelonephritis and obstructive uropathy.

Conclusions:

  • Reactive thrombocytosis can uncommonly exceed 1000 × 109/L.
  • Markedly elevated platelet counts in the context of urinary tract infections may indicate underlying obstructive uropathy.
  • This case underscores the importance of considering urological causes in patients with unexplained thrombocytosis and UTI symptoms.