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Improving glioma drug delivery: A multifaceted approach for glioma drug development

Marybeth G Yonk1, Megan A Lim2, Charee M Thompson3

  • 1Department of Neurosurgery, Emory University School of Medicine, Atlanta, GA, USA; College of Sciences, Georgia Institute of Technology, Atlanta, GA, USA.

Pharmacological Research
|September 5, 2024
PubMed

Insights

Developing new glioma treatments faces challenges due to the blood-brain barrier (BBB) and blood-spinal cord barrier (BSCB). Computational models and novel delivery methods can improve drug efficacy for brain and spinal cord cancers.

Area of Science:

  • Neuro-oncology
  • Pharmacology
  • Biomedical Engineering

Background:

  • Glioma is a common central nervous system (CNS) cancer affecting the brain and spinal cord.
  • The blood-brain barrier (BBB) and blood-spinal cord barrier (BSCB) impede effective drug delivery to CNS tumors.
  • Current FDA-approved glioma treatments have limitations in crossing these barriers.

Purpose of the Study:

  • To review the limitations of current Food and Drug Administration (FDA)-approved glioma treatments.
  • To explore the role of computational BBB/BSCB models in drug development.
  • To highlight innovative drug delivery mechanisms for improved glioma therapy.

Main Methods:

  • Literature review of current glioma treatments and their challenges.
  • Analysis of pharmacokinetic properties and barrier penetration.
  • Exploration of computational modeling and advanced drug delivery systems.

Main Results:

  • Existing glioma therapies exhibit limited efficacy due to poor BBB/BSCB penetration.
  • Computational models offer predictive insights into drug transport across CNS barriers.
  • Innovative delivery strategies show promise for enhancing therapeutic targeting.

Conclusions:

  • Addressing pharmacological profiles and delivery techniques is crucial for advancing glioma treatment.
  • Integrating computational BBB/BSCB models can accelerate the development of novel and repurposed drugs.
  • Improved drug delivery is essential for increasing the efficacy of glioma therapies.
Keywords:
Blood-brain barrierBlood-spinal cord barrierComputational modelDrug deliveryGliomaTherapeutics

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