Binaphthyl-based chiral covalent organic frameworks for chiral drug separation
Hui-Chao Ma1, Hai-Ping Jiang1, Zi-Hui Yao1
1College of Chemistry, Chemical Engineering and Materials Science, Collaborative Innovation Center of Functionalized Probes for Chemical Imaging in Universities of Shandong, Key Laboratory of Molecular and Nano Probes, Ministry of Education, Shandong Normal University, Jinan 250014, P. R. China. huichaoma@sdnu.edu.cn.
Chiral covalent organic frameworks ((R)-BHTP-COF) were synthesized and used as chiral stationary phases for high-performance liquid chromatography (HPLC). These novel materials efficiently separated racemic drugs, demonstrating their potential for pharmaceutical analysis.
Area of Science:
- Materials Science
- Analytical Chemistry
- Organic Chemistry
Background:
- Chiral drug separation is crucial in pharmacology and chemistry.
- Developing efficient chiral stationary phases (CSPs) for chromatography is an ongoing challenge.
Purpose of the Study:
- To synthesize novel binaphthyl-based chiral covalent organic frameworks (CCOFs) designated as (R)-BHTP-COF.
- To evaluate the efficacy of (R)-BHTP-COF as a CSP in high-performance liquid chromatography (HPLC).
Main Methods:
- Bottom-up synthesis of (R)-BHTP-COF.
- Preparation of HPLC columns utilizing (R)-BHTP-COF as the CSP.
- Chromatographic separation of racemic ibuprofen and six other racemic drugs.
Main Results:
- Successful baseline separation of racemic ibuprofen with high selectivity (α = 2.32) and resolution (Rs = 3.39).
- Demonstrated high resolution, selectivity, and durability in separating six different racemic drugs.
- (R)-BHTP-COF exhibited excellent performance as a chiral stationary phase.
Conclusions:
- The synthesized (R)-BHTP-COF shows significant potential as a novel CSP for efficient HPLC.
- CCOFs offer a promising platform for advanced chiral separations in pharmaceutical applications.
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