Binaphthyl-based chiral covalent organic frameworks for chiral drug separation

Hui-Chao Ma1, Hai-Ping Jiang1, Zi-Hui Yao1

  • 1College of Chemistry, Chemical Engineering and Materials Science, Collaborative Innovation Center of Functionalized Probes for Chemical Imaging in Universities of Shandong, Key Laboratory of Molecular and Nano Probes, Ministry of Education, Shandong Normal University, Jinan 250014, P. R. China. huichaoma@sdnu.edu.cn.

Chemical Communications (Cambridge, England)
|September 5, 2024
PubMed
Summary

Chiral covalent organic frameworks ((R)-BHTP-COF) were synthesized and used as chiral stationary phases for high-performance liquid chromatography (HPLC). These novel materials efficiently separated racemic drugs, demonstrating their potential for pharmaceutical analysis.

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