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Updated: Jun 14, 2025

Developing a Rat Model for Bipolar Disorder
Published on: May 2, 2025
Initial dosage optimization of olanzapine in patients with bipolar disorder based on model-informed precision dosing:
Xiao Chen1, Ke Hu2, Hao-Zhe Shi2
1School of Nursing, Xuzhou Medical University, Xuzhou, Jiangsu, China.
Objectives:
Olanzapine is used for treating bipolar disorder (BPD); however, the optimal initial dosing regimen is unclear. The present study aimed to investigate the optimal olanzapine initial dosage in patients with BPD via model-informed precision dosing (MIPD) based on a real-world study.
Methods:
Thirty-nine patients with BPD from the real-world study were collected to construct the MIPD model.
Results:
Weight, combined used quetiapine influenced olanzapine clearances in patients with BPD, where the clearance rates were 0.152:1 in patients with or without quetiapine under the same weight. We simulated olanzapine doses once a day or twice a day, of which twice a day was optimal. Without quetiapine, for twice-a-day olanzapine doses, 0.80, 0.70, and 0.60 mg/kg/day were suitable for 40- to 56-kg BPD patients, 56- to 74-kg BPD patients, and 74- to 100-kg BPD patients, respectively. With quetiapine, for twice-a-day olanzapine doses, 0.05 mg/kg/day was suitable for 40- to 100-kg BPD patients.
Conclusion:
This study was the first to investigate the optimal olanzapine initial dosage in patients with BPD via MIPD based on a real-world study, providing clinical reference for the precision medication of olanzapine in BPD patients.
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