Characterisation of the novel HLA-DPA1*01:12:03 allele by sequencing-based typing
Marine Cargou1, Marco Andreani2, Mariarosa Battarra2
1CHU de Bordeaux, Laboratoire d'Immunologie et Immunogénétique, Hôpital Pellegrin, Bordeaux, France.
HLA
|September 5, 2024
Summary
A novel Human Leukocyte Antigen DPA1 variant, HLA-DPA1*01:12:03, has been identified. This new HLA-DPA1 allele differs from a known allele by a single nucleotide substitution.
Area of Science:
- Immunogenetics
- Molecular Biology
Background:
- Human Leukocyte Antigen (HLA) genes are crucial for immune response.
- Genetic variations in HLA alleles can impact immune system function and disease susceptibility.
Purpose of the Study:
- To characterize a newly identified HLA-DPA1 allele.
- To describe the specific genetic difference between this new allele and a previously known one.
Main Methods:
- Nucleotide sequencing of the HLA-DPA1 gene.
- Comparative analysis of DNA sequences to identify variations.
Main Results:
- A new HLA-DPA1 allele, designated HLA-DPA1*01:12:03, was identified.
- This allele differs from HLA-DPA1*01:12:01 by a single nucleotide substitution.
- The substitution is located at codon 204 within exon 4 of the gene.
Conclusions:
- The identification of HLA-DPA1*01:12:03 expands the known repertoire of HLA-DPA1 alleles.
- This specific nucleotide change may have implications for HLA typing and immunological studies.
