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Characterisation of the Novel HLA-DPB1*04:01:116 Allele by Sequencing-Based Typing
Lucie Blandin1,2, Elodie Wojciechowski3, Mamy Ralazamahaleo3
1Histocompatibility and Immunogenetics Laboratory, Clermont-Ferrand University Hospital, Clermont-Ferrand, France.
HLA
|July 18, 2026
Summary
A novel HLA-DPB1*04:01:116 variant was identified, differing from the known HLA-DPB1*04:01:01:01 by a single nucleotide substitution. This finding contributes to the understanding of human leukocyte antigen diversity.
Area of Science:
- Immunogenetics
- Molecular Biology
Background:
- Human Leukocyte Antigen (HLA) genes are highly polymorphic and crucial for immune response.
- Specific HLA alleles, such as HLA-DPB1, play a significant role in immune system function and disease susceptibility.
Purpose of the Study:
- To characterize a newly identified variant of the HLA-DPB1 gene.
- To detail the specific genetic difference between the novel variant and a known allele.
Main Methods:
- Nucleotide sequencing of the HLA-DPB1 gene.
- Comparative sequence analysis to identify genetic variations.
Main Results:
- A novel HLA-DPB1 allele, designated HLA-DPB1*04:01:116, was identified.
- This new allele differs from HLA-DPB1*04:01:01:01 by a single nucleotide substitution located in codon 43 of exon 2.
Conclusions:
- The discovery of HLA-DPB1*04:01:116 expands the known repertoire of HLA-DPB1 alleles.
- This genetic variation may have implications for immune response and transplantation compatibility.
