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Characterisation of the Novel HLA-C*05:315 Allele by Sequencing-Based Typing
Lucie Blandin1,2, Jonathan Visentin3,4, Marine Cargou3
1Histocompatibility and Immunogenetics Laboratory, Clermont-Ferrand University Hospital, Clermont-Ferrand, France.
HLA
|March 24, 2026
Summary
A novel HLA-C*05:315 allele was identified, differing from HLA-C*05:01:01:02 by a single nucleotide substitution. This finding contributes to the understanding of human leukocyte antigen diversity.
Area of Science:
- Immunogenetics
- Molecular biology
Background:
- Human Leukocyte Antigen (HLA) genes are highly polymorphic.
- Understanding HLA allele variations is crucial for transplantation and disease association studies.
Purpose of the Study:
- To characterize a newly identified HLA-C allele, HLA-C*05:315.
- To describe the specific genetic difference between HLA-C*05:315 and a known allele.
Main Methods:
- Nucleotide sequencing of the HLA-C gene.
- Comparative analysis of DNA sequences.
Main Results:
- HLA-C*05:315 was identified and characterized.
- A single nucleotide substitution at codon 304 in exon 5 distinguishes HLA-C*05:315 from HLA-C*05:01:01:02.
Conclusions:
- The discovery of HLA-C*05:315 expands the known repertoire of HLA-C alleles.
- This specific substitution may have implications for immune responses and HLA typing accuracy.
