Related Experiment Video

Updated: Jun 14, 2025

Isolation of Viable Adipocytes and Stromal Vascular Fraction from Human Visceral Adipose Tissue Suitable for RNA Analysis and Macrophage Phenotyping
06:22

Isolation of Viable Adipocytes and Stromal Vascular Fraction from Human Visceral Adipose Tissue Suitable for RNA Analysis and Macrophage Phenotyping

Published on: October 27, 2020

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Impact of Visceral and Hepatic Fat on Cardiometabolic Health

Tasveer Khawaja1,2, Matthew Nied2, Abigail Wilgor2

  • 1Harrington Heart and Vascular Institute, University Hospitals Cleveland and Case Western Reserve University, Cleveland, OH, USA.

Current Cardiology Reports
|September 5, 2024
PubMed

Insights

Visceral fat strongly links to heart disease, while hepatic fat

Area of Science:

  • Cardiology
  • Endocrinology
  • Metabolic Disorders

Background:

  • Body fat distribution significantly impacts cardiometabolic health.
  • Visceral and hepatic fat depots are key areas of concern in obesity.

Purpose of the Study:

  • To review the impact of visceral and hepatic fat on cardiometabolic outcomes.
  • To highlight current and emerging interventions for managing ectopic fat.

Main Methods:

  • Review of epidemiologic studies and recent clinical evidence.
  • Analysis of pharmacologic and lifestyle interventions.
  • Evaluation of surgical and emerging therapeutic strategies.

Main Results:

  • Visceral fat is clearly associated with cardiovascular disease.
  • Hepatic fat's link to cardiovascular disease is less definitive.
  • Sodium-glucose co-transporter-2 (SGLT2) inhibitors and glucagon-like peptide-1 (GLP-1) receptor agonists show promise in reducing ectopic fat and cardiometabolic risk.

Conclusions:

  • Visceral fat has established cardiometabolic consequences.
  • Hepatic fat's role requires further clarification.
  • Lifestyle, pharmacologic, and surgical interventions, alongside emerging therapies, are crucial for managing body fat distribution and cardiometabolic risk.
Abstract

Keywords:
Cardiometabolic riskGLP-1 RAHepatic fatObesitySGLT2iVisceral fat

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