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Related Concept Videos

Type II Diabetes II: Pathophysiology01:24

Type II Diabetes II: Pathophysiology

PathophysiologyType 2 diabetes mellitus (T2DM ) is a chronic metabolic disorder characterized by insulin resistance and progressive pancreatic β-cell dysfunction, leading to impaired glucose homeostasis. It results from interactions among genetic predisposition, environmental factors, and metabolic stressors, such as overnutrition and a sedentary lifestyle.Insulin Resistance and Glucose DysregulationEarly T2DM involves insulin resistance in skeletal muscle, adipose tissue, and the liver.

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Long-term Metabolic Dysfunction Programming in Female Mice by Serial Moderate Restriction of a High-fat High-sucrose

Micah P Wildes1,2,3, Deemantha G Fernando2, Connie C Grobe4

  • 1Department of Physiology, Medical College of Wisconsin, Milwaukee, WI 53226, USA.

Endocrinology
|September 5, 2024
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Repeated intermittent food restriction in female mice led to impaired glucose tolerance and altered eating behaviors. These changes persisted even after returning to continuous feeding, suggesting long-term metabolic consequences.

Keywords:
energy balancefeeding behaviorglucose intoleranceintermittent calorie restriction

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Area of Science:

  • Metabolic health
  • Nutritional science
  • Animal models

Background:

  • Intermittent fasting aids weight loss and glucose metabolism.
  • Food insecurity is linked to obesity and cardiometabolic issues, particularly in women.

Purpose of the Study:

  • To investigate the effects of intermittent feeding on energy balance and glucose tolerance in female mice.

Main Methods:

  • Female mice on a high-fat, high-sucrose diet were intermittently food-restricted from weaning until week 19.
  • Body composition, energy balance, glucose tolerance, and hormone levels were assessed.

Main Results:

  • Intermittent food restriction reduced weight and fat mass during the restriction period.
  • After refeeding, restricted mice showed increased food intake and body mass, with impaired glucose tolerance.
  • Trends indicated lower levels of key appetite-regulating hormones.

Conclusions:

  • Repeated intermittent food restriction can alter eating behaviors, leading to glucose intolerance when food is freely available.
  • Further research is required to understand the underlying mechanisms of these metabolic changes.