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Sarcopenia in cirrhosis: From pathophysiology to interventional therapy
Huiling Chen1, Chenyun Yang2, Shijie Yan3
1Department of Endocrinology, Shanghai Pudong Hospital, Fudan University Pudong Medical Center, 2800 Gongwei Road, Pudong, Shanghai 201399, China; Fudan University, Shanghai, China.
Experimental Gerontology
|September 5, 2024
Summary
Sarcopenia, the loss of muscle mass and function, worsens outcomes for cirrhosis patients. Early diagnosis and treatment are crucial for improving patient management and reducing complications.
Area of Science:
- Hepatology and Geriatrics
Background:
- Sarcopenia, characterized by loss of skeletal muscle mass and function, is a major complication in cirrhosis patients.
- It increases morbidity, mortality, hospitalization, infections, and hepatic encephalopathy risk.
- Sarcopenia in cirrhosis is often underdiagnosed and undertreated.
Purpose of the Study:
- To review the pathophysiology of sarcopenia in cirrhosis.
- To discuss diagnostic challenges and emerging therapeutic strategies.
- To identify research gaps and future directions for managing sarcopenic cirrhotic patients.
Main Methods:
- Literature review of current knowledge on sarcopenia in cirrhosis.
- Analysis of pathophysiological mechanisms, diagnostic methods, and treatments.
- Synthesis of information to propose future research avenues.
Main Results:
- Sarcopenia significantly impacts cirrhosis patient outcomes.
- Key mechanisms include altered metabolism, hormonal imbalances, and inflammation.
- Nutritional support, exercise, and pharmacological interventions show therapeutic potential.
Conclusions:
- Effective management of sarcopenia is vital for improving cirrhotic patients' quality of life and prognosis.
- Further research is needed to refine diagnostic tools and therapeutic strategies.
- Integrated approaches addressing muscle loss are essential for comprehensive cirrhosis care.
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