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Beta-Hydroxybutyrate: A Supplemental Molecule for Various Diseases.
Navid Reza Shahtaghi1, Bindu Soni1, Hossamaldeen Bakrey1
1Department of Pharmaceutical Sciences, Guru Nanak Dev University, 143005, Amritsar, Punjab, India.
Current Drug Targets
|September 6, 2024
Summary
Beta-hydroxybutyrate (BHB) supplementation can induce nutritional ketosis for energy. This review explores BHB
Area of Science:
- Metabolic biochemistry
- Nutritional science
- Cellular signaling
Background:
- Beta-hydroxybutyrate (BHB) is a ketone body utilized as an alternative energy source by tissues like the brain and heart.
- BHB functions as both a metabolic intermediate and a signaling molecule, influencing cellular and physiological functions.
- BHB supplementation presents a strategy to achieve nutritional ketosis without strict diets.
Purpose of the Study:
- To review BHB metabolism and its therapeutic applications, particularly in age-related diseases.
- To synthesize findings on BHB's potential benefits and challenges for various health conditions.
- To outline future research directions for BHB supplementation.
Main Methods:
- Comprehensive literature search of PubMed, ScienceDirect, and other relevant databases.
- Synthesis and discussion of findings from existing English-language articles.
- Analysis of BHB's mechanisms, benefits, challenges, and future prospects.
Main Results:
- BHB supplementation shows potential benefits for neurodegenerative disorders, cardiovascular diseases, cancers, and inflammation.
- BHB exerts its effects through diverse mechanisms, including receptor interactions, enzyme modulation, and epigenetic modifications.
- Challenges include determining optimal dosage, ensuring safety, and identifying effective formulations.
Conclusions:
- BHB supplementation is a promising area for health research, potentially enhancing well-being and lifespan.
- Further research is needed to optimize strategies, understand molecular mechanisms, and assess long-term benefits.
- BHB offers a novel approach to managing various diseases and improving healthspan.
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