Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Introduction to the Human Microbiota01:22

Introduction to the Human Microbiota

209
Microorganisms colonize various regions of the human body, including the mouth, nasal passages, throat, stomach, intestines, urogenital tract, and skin. The total number of microbial cells is estimated to range from 10¹³ to 10¹⁴—comparable to, or exceeding, the number of human somatic cells. This host–microbiome relationship has led to the conceptualization of humans as supraorganisms, wherein microbial communities perform vital roles in development, immunity,...
209
Development of Human Microbiota01:30

Development of Human Microbiota

61
The human microbiota begins developing at birth and undergoes continual change as we age. Infancy marks a critical period of microbial sensitivity, offering a “window of opportunity” during which beneficial microbes help mature the immune system. By age three, children typically develop a more stable and diverse microbial community. Newborns acquire microbes from their immediate environment; vaginal delivery favors maternal vaginal microbes, while cesarean births favor microbes from...
61
Microbiota of the Stomach and Small Intestine01:27

Microbiota of the Stomach and Small Intestine

77
The human gastrointestinal (GI) tract is characterized by distinct physicochemical conditions that shape its microbial communities. Among these, the stomach presents a particularly challenging environment for microbial colonization due to its highly acidic pH, ranging from 1 to 3. This extreme acidity effectively limits microbial density. However, certain acid-tolerant microorganisms are capable of surviving in this niche. Notably, Helicobacter pylori can colonize the gastric mucosa,...
77
Microbiota of the Large Intestine01:27

Microbiota of the Large Intestine

98
The large intestine hosts the most densely populated microbial ecosystem in the human body. This complex community primarily consists of anaerobic bacteria, with Bacillota (formerly Firmicutes) and Bacteroidota (formerly Bacteroidetes) as the predominant groups. The distribution of these microbes varies along different sections of the large intestine, influenced by local environmental factors such as oxygen availability and nutrient composition.The cecum, located at the beginning of the large...
98
Functions of the Gut Microbiota01:18

Functions of the Gut Microbiota

233
The gut microbiota includes trillions of microorganisms that colonize the human gastrointestinal tract, including bacteria, archaea, viruses, and fungi. This complex ecosystem plays a critical role in maintaining intestinal and systemic health. Most of these microbes inhabit the large intestine, establishing a relatively stable and diverse community that contributes to gut homeostasis through various metabolic, immunological, and protective mechanisms.Dominant bacterial phyla, such as...
233
Bacterial Gastroenteritis01:18

Bacterial Gastroenteritis

88
Bacterial gastroenteritis, characterized by diarrhea, abdominal cramps, and vomiting, is often caused by ingestion of contaminated food or water and is frequently associated with pathogenic Escherichia coli strains. These microbes exploit two principal mechanisms to inflict disease.Shiga toxin–producing E. coli, also referred to as STEC—notably O157:H7—release Shiga toxins that target ribosomes, blocking protein synthesis. The B subunit of the toxin binds the host glycolipid...
88

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Multi-Feature Fusion and Optimization for <i>Micropterus salmoides</i> Tracking and Body Length Monitoring in Complex Aquaculture Environments.

Sensors (Basel, Switzerland)·2026
Same author

Broadband Photodetector Based on Monolayer MoS<sub>2</sub> Hybridized with Eco-Friendly CuInS<sub>2</sub> Quantum Dots for Weak-to-Strong Light Detection.

ACS applied materials & interfaces·2026
Same author

Inhaled nitric oxide for reducing major adverse events requiring intensive life support in adults undergoing cardiac surgery with cardiopulmonary bypass: protocol for a phase III, double-blind, multicenter randomized controlled trial (NORISC Trial).

Nitric oxide : biology and chemistry·2026
Same author

Automatic optimization method of horizontal well formation model based on natural gamma while drilling.

Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine·2026
Same author

Responses of Soil Nitrogen-Cycling Microbial Communities and Functional Potential to Grazing Intensities in Alpine Meadows.

Microorganisms·2026
Same author

Polyubiquitination and accumulation of PEG10 regulated by SIAH1/2 affiliates the progression of hepatocellular carcinoma.

Cell communication and signaling : CCS·2026

Related Experiment Video

Updated: May 1, 2026

Colon Ascendens Stent Peritonitis CASP - a Standardized Model for Polymicrobial Abdominal Sepsis
06:45

Colon Ascendens Stent Peritonitis CASP - a Standardized Model for Polymicrobial Abdominal Sepsis

Published on: December 18, 2010

19.5K

[Research progress on the correlation between intestinal microecology and sepsis].

Zhiyi Liu1,2, Guanghui Xiu1,2

  • 1Department of Intensive Care Unit, Affiliated Hospital of Yunnan University (the Second People's Hospital of Yunnan Province), Kunming 650021, Yunnan, China.

Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
|September 6, 2024
PubMed
Summary

Sepsis, a life-threatening condition, involves organ dysfunction due to infection. Reconstructing the gut microbiota offers promising therapeutic strategies to improve sepsis patient outcomes.

More Related Videos

A Controlled Mouse Model for Neonatal Polymicrobial Sepsis
14:54

A Controlled Mouse Model for Neonatal Polymicrobial Sepsis

Published on: January 27, 2019

11.0K
Design of Cecal Ligation and Puncture and Intranasal Infection Dual Model of Sepsis-Induced Immunosuppression
07:30

Design of Cecal Ligation and Puncture and Intranasal Infection Dual Model of Sepsis-Induced Immunosuppression

Published on: June 15, 2019

10.0K

Related Experiment Videos

Last Updated: May 1, 2026

Colon Ascendens Stent Peritonitis CASP - a Standardized Model for Polymicrobial Abdominal Sepsis
06:45

Colon Ascendens Stent Peritonitis CASP - a Standardized Model for Polymicrobial Abdominal Sepsis

Published on: December 18, 2010

19.5K
A Controlled Mouse Model for Neonatal Polymicrobial Sepsis
14:54

A Controlled Mouse Model for Neonatal Polymicrobial Sepsis

Published on: January 27, 2019

11.0K
Design of Cecal Ligation and Puncture and Intranasal Infection Dual Model of Sepsis-Induced Immunosuppression
07:30

Design of Cecal Ligation and Puncture and Intranasal Infection Dual Model of Sepsis-Induced Immunosuppression

Published on: June 15, 2019

10.0K

Area of Science:

  • Critical care medicine
  • Microbiology
  • Immunology

Background:

  • Sepsis is a leading cause of death, characterized by organ dysfunction from a dysregulated host response to infection.
  • Pathophysiological mechanisms include vascular endothelial dysfunction, microcirculatory disorders, and immune suppression.
  • Gut microbiota dysbiosis is increasingly recognized as a significant factor in sepsis development and progression.

Purpose of the Study:

  • To review current research on the association between gut microbiota and sepsis.
  • To explore the potential of gut microbiota modulation as a therapeutic strategy for sepsis.
  • To provide clinicians with insights for improving sepsis patient prognosis.

Main Methods:

  • Literature review of studies investigating the gut microbiome in sepsis.
  • Analysis of mechanisms linking gut dysbiosis to sepsis-induced organ dysfunction.
  • Synthesis of findings on therapeutic interventions targeting the gut microbiota in sepsis.

Main Results:

  • Gut microbiota imbalance is closely linked to sepsis development and severity.
  • Specific microbial alterations correlate with organ dysfunction and mortality in sepsis patients.
  • Modulating the gut microbiota shows potential for improving sepsis outcomes.

Conclusions:

  • The gut microbiome plays a critical role in sepsis pathogenesis.
  • Targeting gut microbiota reconstruction presents a promising avenue for novel sepsis therapies.
  • Further research is warranted to translate these findings into effective clinical practice.