Related Experiment Video

Updated: Jun 14, 2025

Isolation and Characterization of Adult Cardiac Fibroblasts and Myofibroblasts
10:45

Isolation and Characterization of Adult Cardiac Fibroblasts and Myofibroblasts

Published on: March 12, 2020

15.8K

Circulating fibrocyte levels correlate with left ventricular mass in middle-aged healthy adults without hypertension

Daniel S Feuer1, Borna Mehrad1,2, Ellen C Keeley1,3

  • 1Department of Medicine, University of Florida, Gainesville, FL, United States of America.

American Heart Journal Plus : Cardiology Research and Practice
|September 6, 2024
PubMed

Insights

Circulating fibrocytes correlate with left ventricular mass in healthy adults. These cells may predict future hypertension development.

Area of Science:

  • Cardiovascular Research
  • Immunology
  • Cell Biology

Background:

  • Fibrocytes, bone marrow-derived cells, contribute to arterial fibrosis in hypertension.
  • Elevated left ventricular (LV) mass is a hallmark of hypertensive cardiovascular damage.

Purpose of the Study:

  • To investigate the association between circulating fibrocytes and LV mass in non-hypertensive adults.
  • To explore fibrocytes as potential early biomarkers for cardiovascular changes.

Main Methods:

  • Peripheral blood samples were collected from 13 middle-aged, non-hypertensive adults.
  • Fibrocyte levels and their activated phenotypes were quantified.
  • Cardiac magnetic resonance imaging (MRI) was used to assess LV mass.

Main Results:

  • A significant correlation was found between total fibrocytes (CD45+Col1+) and LV mass index (r=0.71, p=0.006).
  • Specific fibrocyte subsets expressing CCR2, CCR5, CCR7, CXCR4, α-SMA, CD133, and pSTAT6 also correlated with LV mass index.
  • These findings suggest fibrocytes are linked to cardiac remodeling even in the absence of hypertension.

Conclusions:

  • Circulating fibrocytes are associated with LV mass index in middle-aged adults without hypertension.
  • Fibrocytes may serve as an early indicator or harbinger for the future development of hypertension and associated cardiac changes.
Abstract

Keywords:
Cardiac magnetic resonance imagingFibrocyteFibrosisLeft ventricular mass

More Related Videos

Murine Echocardiography of Left Atrium, Aorta, and Pulmonary Artery08:17

Murine Echocardiography of Left Atrium, Aorta, and Pulmonary Artery

Published on: February 20, 2017

14.3K
Noninvasive Determination of Vortex Formation Time Using Transesophageal Echocardiography During Cardiac Surgery04:48

Noninvasive Determination of Vortex Formation Time Using Transesophageal Echocardiography During Cardiac Surgery

Published on: November 28, 2018

7.9K

Related Concept Videos

Blood Studies for Cardiovascular System I: Cardiac Biomarkers01:20

Blood Studies for Cardiovascular System I: Cardiac Biomarkers

Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
119
Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers01:19

Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers

Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
68
Imbalances in Cardiac Output01:26

Imbalances in Cardiac Output

The heart's primary function is to pump blood throughout the body, maintaining a balance between blood sent out (cardiac output) and blood returning (venous return). If this balance is disrupted, it can result in congestive heart failure (CHF), a severe condition where the heart becomes an inefficient pump, leading to inadequate blood circulation.
CHF can occur due to the failure of either side of the heart. Left-side failure leads to pulmonary congestion—the right side continues to send...
1.4K
Pathophysiology of Heart Failure01:17

Pathophysiology of Heart Failure

Heart failure (HF) is a progressive syndrome involving ventricles that leads to inadequate cardiac output. It can be classified based on location and output or ejection fraction. Ejection fraction (EF) is an essential measurement in the diagnosis and surveillance of HF. Reduced EF corresponds to systolic heart failure (HFrEF). However, HF with preserved ejection fraction (HFpEF) is becoming increasingly prevalent. Also known as diastolic HF, this form of HF is related to aging. The...
1.5K
Blood Studies for Cardiovascular System III: Serum Lipid Profile01:25

Blood Studies for Cardiovascular System III: Serum Lipid Profile

Understanding serum lipids is crucial for maintaining cardiovascular health and preventing heart disease and stroke.
Serum lipids are fats and fatty substances in the blood and are crucial for various bodily functions, including energy storage, cellular structure, and hormone production. Serum lipids consist of cholesterol, triglycerides, and phospholipids.
Cholesterol is a soft, fat-like substance found in all body cells. It is crucial for producing hormones, vitamin D, and substances that aid...
140